Lund University is celebrating 350 years. Read more on lunduniversity.lu.se

Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.

Author:
  • Alina Oknianska
  • Emilia Zmuda-Trzebiatowska
  • Vincent Manganiello
  • Eva Degerman
Publishing year: 2007
Language: English
Pages: 1080-1085
Publication/Series: Biochemical and Biophysical Research Communications
Volume: 353
Issue: 4
Document type: Journal article
Publisher: Elsevier

Abstract english

Phosphodiesterase 3B (PDE3B), is known to play an important role in acute insulin and cAMP-mediated regulation of lipid metabolism, and PDE4 are the main PDE types expressed in adipocytes. Here, we show that members of all PDE4 isoforms are expressed in 3T3-L1 and primary mouse adipocytes. Long-term treatment of 3T3-L1 adipocytes with insulin induced up-regulation of PDE3B and PDE4D in a phosphatidylinositol 3-kinase-dependent manner whereas long-term treatment with P-adrenergic agonists induced down-regulation of PDE3B and up-regulation of PDE4D. Thus, PDE3B and PDE4D can be added to the list of genes regulated by insulin and cAMP-increasing hormones. Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin and catecholamines may contribute to altered regulation of metabolism in diabetes. (c) 2006 Elsevier Inc. All rights reserved.

Keywords

  • Biological Sciences
  • phosphodiesterase 3B
  • phosphodiesterase 4
  • adipocyte
  • insulin
  • isoproterenol

Other

Published
  • Insulin Signal Transduction
  • ISSN: 1090-2104
Eva Degerman
E-mail: eva [dot] degerman [at] med [dot] lu [dot] se

Professor

Insulin Signal Transduction

+46 46 222 85 83

+46 70 885 83 62

BMC C1121b

66

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00