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Erik Renström

Erik Renström

Vice-chancellor

Erik Renström

PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells

Author

  • Lena Eliasson
  • Erik Renström
  • Carina Ammala
  • Per-Olof Berggren
  • Alejandro M. Bertorello
  • Krister Bokvist
  • Alexander Chibalin
  • Jude T. Deeney
  • Peter R. Flatt
  • Jakob Gabel
  • Jesper Gromada
  • Olof Larsson
  • Per Lindstrom
  • Christopher J. Rhodes
  • Patrik Rorsman

Summary, in English

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.

Department/s

  • Diabetes - Islet Patophysiology

Publishing year

1996

Language

English

Pages

813-815

Publication/Series

Science

Volume

271

Issue

5250

Document type

Journal article

Publisher

American Association for the Advancement of Science

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Islet Patophysiology

ISBN/ISSN/Other

  • ISSN: 1095-9203