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Erik Renström

Erik Renström

Vice-chancellor

Erik Renström

Ion channels, electrical activity and insulin secretion

Author

  • Patrik Rorsman
  • K Bokvist
  • C Ammala
  • L Eliasson
  • Erik Renström
  • J Gabel

Summary, in English

The insulin-secreting pancreatic beta cell is electrically excitable and changes in the membrane potential play an important role in coupling the metabolism of glucose (and other nutrient secretagogues) to the discharge of the insulin-containing granule. The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion channels, to pancreatic islet cells has revolutionized our understanding of the beta cell electrophysiology. Here we review some of the recent progress in the field. The properties of functionally important ion channels are described and their possible roles are discussed.

Department/s

  • Islet cell physiology
  • Diabetes - Islet Patophysiology

Publishing year

1994

Language

English

Pages

138-145

Publication/Series

Diabete & metabolisme

Volume

20

Issue

2

Document type

Journal article

Publisher

Elsevier Masson SAS

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Islet cell physiology
  • Diabetes - Islet Patophysiology

ISBN/ISSN/Other

  • ISSN: 0338-1684