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Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice with Severe Acute Pancreatitis.

Author:
  • Mohammed Merza
  • Hannes Hartman Magnusson
  • Milladur Rahman
  • Rundk Hwaiz
  • Enming Zhang
  • Erik Renström
  • Lingtao Luo
  • Matthias Mörgelin
  • Sara Regnér
  • Henrik Thorlacius
Publishing year: 2015
Language: English
Pages: 1920-1920
Publication/Series: Gastroenterology
Volume: 149
Issue: 7
Document type: Journal article
Publisher: W B Saunders

Abstract english

Neutrophils are involved in development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported contribute to organ dysfunction in patients with infectious diseases. We investigated whether NETs contribute to development of AP in mice.

Keywords

  • Gastroenterology and Hepatology

Other

Published
  • Surgery Research
  • Islet patophysiology
  • ISSN: 1528-0012
Erik Renström
E-mail: erik [dot] renstrom [at] med [dot] lu [dot] se

Deputy head of department

Department of Clinical Sciences, Malmö

+46 40 39 11 57

+46 40 39 11 57

Principal investigator

Islet patophysiology

+46 40 39 11 57

+46 40 39 11 57

20-3-308

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