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Erik Renström

Erik Renström

Vice-chancellor

Erik Renström

Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice with Severe Acute Pancreatitis.

Author

  • Mohammed Merza
  • Hannes Hartman Magnusson
  • Milladur Rahman
  • Rundk Hwaiz
  • Enming Zhang
  • Erik Renström
  • Lingtao Luo
  • Matthias Mörgelin
  • Sara Regnér
  • Henrik Thorlacius

Summary, in English

Neutrophils are involved in development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported contribute to organ dysfunction in patients with infectious diseases. We investigated whether NETs contribute to development of AP in mice.

Department/s

  • Surgery
  • Diabetes - Islet Patophysiology
  • Infection Medicine (BMC)
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2015

Language

English

Pages

1920-1920

Publication/Series

Gastroenterology

Volume

149

Issue

7

Document type

Journal article

Publisher

Elsevier

Topic

  • Gastroenterology and Hepatology

Status

Published

Research group

  • Surgery
  • Diabetes - Islet Patophysiology

ISBN/ISSN/Other

  • ISSN: 1528-0012