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Erik Renström

Erik Renström


Erik Renström

The adult human brain harbors multipotent perivascular mesenchymal stem cells.


  • Gesine Paul-Visse
  • Ilknur Ozen
  • Nicolaj Christophersen
  • Thomas Reinbothe
  • Johan Bengzon
  • Edward Visse
  • Katarina Jansson
  • Karin Dannaeus
  • Catarina Henriques-Oliveira
  • Laurent Roybon
  • Sergey Anisimov
  • Erik Renström
  • Mikael Svensson
  • Anders Haegerstrand
  • Patrik Brundin

Summary, in English

Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this perivascular niche, a stem cell with mesenchymal characteristics was recently identified in some adult somatic tissues. These cells are pericytes that line the microvasculature, express mesenchymal markers and differentiate into mesodermal lineages but might even have the capacity to generate tissue-specific cell types. Here, we isolated, purified and characterized a previously unrecognized progenitor population from two different regions in the adult human brain, the ventricular wall and the neocortex. We show that these cells co-express markers for mesenchymal stem cells and pericytes in vivo and in vitro, but do not express glial, neuronal progenitor, hematopoietic, endothelial or microglial markers in their native state. Furthermore, we demonstrate at a clonal level that these progenitors have true multilineage potential towards both, the mesodermal and neuroectodermal phenotype. They can be epigenetically induced in vitro into adipocytes, chondroblasts and osteoblasts but also into glial cells and immature neurons. This progenitor population exhibits long-term proliferation, karyotype stability and retention of phenotype and multipotency following extensive propagation. Thus, we provide evidence that the vascular niche in the adult human brain harbors a novel progenitor with multilineage capacity that appears to represent mesenchymal stem cells and is different from any previously described human neural stem cell. Future studies will elucidate whether these cells may play a role for disease or may represent a reservoir that can be exploited in efforts to repair the diseased human brain.


  • Department of Experimental Medical Science
  • Neurology, Lund
  • Diabetes - Islet Patophysiology
  • Section IV
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year










Document type

Journal article


Public Library of Science


  • Neurosciences
  • Endocrinology and Diabetes
  • Neurology



Research group

  • Diabetes - Islet Patophysiology


  • ISSN: 1932-6203