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The Cell Physiology of Biphasic Insulin Secretion

Author:
  • Patrik Rorsman
  • Lena Eliasson
  • Erik Renström
  • Jesper Gromada
  • Sebastian Barg
  • Sven Göpel
Publishing year: 2000
Language: English
Pages: 72-77
Publication/Series: News in Physiological Sciences - Nips
Volume: 15
Issue: 2
Document type: Journal article
Publisher: American Physiological Society

Abstract english

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Islet cell physiology
  • Islet cell exocytosis
  • Islet patophysiology
  • ISSN: 1522-161X
Erik Renström
E-mail: erik [dot] renstrom [at] med [dot] lu [dot] se

Deputy head of department

Department of Clinical Sciences, Malmö

+46 40 39 11 57

+46 40 39 11 57

Principal investigator

Islet patophysiology

+46 40 39 11 57

+46 40 39 11 57

20-3-308

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Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00