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Erik Renström

Erik Renström

Vice-chancellor

Erik Renström

The Cell Physiology of Biphasic Insulin Secretion

Author

  • Patrik Rorsman
  • Lena Eliasson
  • Erik Renström
  • Jesper Gromada
  • Sebastian Barg
  • Sven Göpel

Summary, in English

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

Department/s

  • Islet cell physiology
  • Diabetes - Islet Cell Exocytosis
  • Diabetes - Islet Patophysiology
  • Department of Experimental Medical Science

Publishing year

2000

Language

English

Pages

72-77

Publication/Series

News in Physiological Sciences

Volume

15

Issue

2

Document type

Journal article

Publisher

American Physiological Society

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Islet cell physiology
  • Diabetes - Islet Cell Exocytosis
  • Diabetes - Islet Patophysiology

ISBN/ISSN/Other

  • ISSN: 1522-161X