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Emma Ahlqvist

Emma Ahlqvist

Assistant researcher

Emma Ahlqvist

The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.

Author

  • Emma Ahlqvist
  • Malin Hultqvist
  • Rikard Holmdahl

Summary, in English

ABSTRACT: For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.

Department/s

  • Immunology

Publishing year

2009

Language

English

Publication/Series

Arthritis Research and Therapy

Volume

11

Issue

3

Document type

Journal article review

Publisher

BioMed Central (BMC)

Topic

  • Rheumatology and Autoimmunity

Status

Published

Research group

  • Immunology

ISBN/ISSN/Other

  • ISSN: 1478-6362