Emma Ahlqvist, Assistant Professor
Our research is focused on personalized medicine in diabetes and the genetics of diabetes related traits.
Diabetes is presently classified into two main forms, type 1 (T1D) and type 2 diabetes (T2D), but both diseases are highly heterogeneous with respect to disease progression, response to medication and risk of developing complications. One of the main goals of the group is to subclassify diabetes into more homogeneous subgroups. Such an improved classification could help tailor and target early treatment to patients who would benefit most, thereby representing a first step towards precision medicine in diabetes.
Genomics provide invaluable tools to elucidate disease mechanisms in an unbiased manner and to identify causal relationships between biomarkers and disease outcomes. We use genome-wide association studies and next-generation sequencing to identify genetic variation that affects risk of diabetes and diabetic complications, as well as related traits, such as hormone secretion and biomarker concentrations. Recently, we have focused on the genetics of incretin hormone secretion and on the role of incretins in human physiology and diabetic complications.
Retrieved from Lund University's publications database
- CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
- Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
- Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
- A Central Role for GRB10 in Regulation of Islet Function in Man.
- Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
- Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
- A link between GIP and osteopontin in adipose tissue and insulin resistance.
- Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
- The human L-type calcium channel Ca(v)1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes.
- A common variant upstream of the PAX6 gene influences islet function in man.
- A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
- Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.
- Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice
- New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
- SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
- Genetics of Type 2 Diabetes.
- Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
- High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice
- Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus