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Emily Sonestedt

Emily Sonestedt

Associate senior lecturer

Emily Sonestedt

Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition.


  • Melissa A Merritt
  • Elio Riboli
  • Elisabete Weiderpass
  • Konstantinos K Tsilidis
  • Kim Overvad
  • Anne Tjønneland
  • Louise Hansen
  • Laure Dossus
  • Guy Fagherazzi
  • Laura Baglietto
  • Renée T Fortner
  • Jennifer Ose
  • Annika Steffen
  • Heiner Boeing
  • Antonia Trichopoulou
  • Dimitrios Trichopoulos
  • Pagona Lagiou
  • Giovanna Masala
  • Sabina Sieri
  • Amalia Mattiello
  • Rosario Tumino
  • Carlotta Sacerdote
  • H B As Bueno-de-Mesquita
  • N Charlotte Onland-Moret
  • Petra H Peeters
  • Anette Hjartåker
  • Inger Torhild Gram
  • J Ramón Quirós
  • Mireia Obón-Santacana
  • Esther Molina-Montes
  • José María Huerta Castaño
  • Eva Ardanaz
  • Saioa Chamosa
  • Emily Sonestedt
  • Annika Idahl
  • Eva Lundin
  • Kay-Tee Khaw
  • Nicholas Wareham
  • Ruth C Travis
  • Sabina Rinaldi
  • Isabelle Romieu
  • Veronique Chajes
  • Marc J Gunter

Summary, in English

There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.


  • Diabetes - Cardiovascular Disease
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year







Cancer Epidemiology





Document type

Journal article




  • Cancer and Oncology



Research group

  • Diabetes - Cardiovascular Disease


  • ISSN: 1877-7821