The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Emily Sonestedt

Emily Sonestedt

Associate senior lecturer

Emily Sonestedt

Dairy products and risk of hepatocellular carcinoma: The European Prospective Investigation into Cancer and Nutrition

Author

  • Talita Duarte-Salles
  • Veronika Fedirko
  • Magdalena Stepien
  • Antonia Trichopoulou
  • Christina Bamia
  • Pagona Lagiou
  • Annekatrin Lukanova
  • Elisabeth Trepo
  • Kim Overvad
  • Anne Tjonneland
  • Jytte Halkjaer
  • Marie-Christine Boutron-Ruault
  • Antoine Racine
  • Claire Cadeau
  • Tilman Kuehn
  • Krasimira Aleksandrova
  • Dimitrios Trichopoulos
  • Konstantinos Tsiotas
  • Paolo Boffetta
  • Domenico Palli
  • Valeria Pala
  • Rosario Tumino
  • Carlotta Sacerdote
  • Salvatore Panico
  • H. B(as) Bueno-de-Mesquita
  • Vincent K. Dik
  • Petra H. Peeters
  • Elisabete Weiderpass
  • Inger Torhild Gram
  • Anette Hjartaker
  • Jose Ramon Quiros
  • Ana Fonseca-Nunes
  • Esther Molina-Montes
  • Miren Dorronsoro
  • Carmen Navarro Sanchez
  • Aurelio Barricarte
  • Bjorn Lindkvist
  • Emily Sonestedt
  • Ingegerd Johansson
  • Maria Wennberg
  • Kay-Tee Khaw
  • Nick Wareham
  • Ruth C. Travis
  • Isabelle Romieu
  • Elio Riboli
  • Mazda Jenab

Summary, in English

Intake of dairy products has been associated with risk of some cancers, but findings are often inconsistent and information on hepatocellular carcinoma (HCC) risk is limited, particularly from prospective settings. The aim of our study was to investigate the association between consumption of total and specific dairy products (milk/cheese/ yogurt) and their components (calcium/vitamin D/fats/protein), with first incident HCC (N-cases=191) in the European Prospective Investigation into Cancer and Nutrition cohort, including a nested case-control subset (N-cases=122) with the assessment of hepatitis B virus/hepatitis C virus infections status, liver damage and circulating insulin-like growth factor (IGF)-I levels. For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. A total of 477,206 participants were followed-up for an average of 11 years (person-years follow-up=5,415,385). In the cohort study, a significant positive HCC risk association was observed for total dairy products (highest vs. lowest tertile, HR=1.66, 95% CI: 1.13-2.43; p(trend)=0.012), milk (HR=1.51, 95% CI: 1.02-2.24; p(trend=)0.049), and cheese (HR=1.56, 95% CI: 1.02-2.38; p(trend)=0.101), but not yogurt (HR=0.94, 95% CI: 0.65-1.35). Dietary calcium, vitamin D, fat and protein from dairy sources were associated with increased HCC risk, whereas the same nutrients from nondairy sources showed inverse or null associations. In the nested case-control study, similar results were observed among hepatitis-free individuals. Results from this large prospective cohort study suggest that higher consumption of dairy products, particularly milk and cheese, may be associated with increased HCC risk. Validation of these findings in other populations is necessary. Potential biologic mechanisms require further exploration. What's new? Currently, the role of dairy product intake in the development of hepatocellular carcinoma (HCC) is unclear. Using detailed data from a large multi-centric prospective cohort, this study investigated the association between consumption of total and specific dairy products with first incident HCC. The study found that higher dairy product consumption, particularly milk and cheese, was associated with increased HCC risk. Dietary calcium, vitamin D, fat and protein did not explain the observed associations. However, higher circulating IGF-I levels may play a role.

Department/s

  • Diabetes - Cardiovascular Disease
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014

Language

English

Pages

1662-1672

Publication/Series

International Journal of Cancer

Volume

135

Issue

7

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Cancer and Oncology

Keywords

  • hepatocellular carcinoma
  • dairy products
  • calcium
  • prospective cohort

Status

Published

Research group

  • Diabetes - Cardiovascular Disease

ISBN/ISSN/Other

  • ISSN: 0020-7136