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Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies

  • Jennifer A. Nettleton
  • Nicola M. McKeown
  • Stavroula Kanoni
  • Rozenn N. Lemaitre
  • Marie-France Hivert
  • Julius Ngwa
  • Frank J. A. van Rooij
  • Emily Sonestedt
  • Mary K. Wojczynski
  • Zheng Ye
  • Tosh Tanaka
Publishing year: 2010
Language: English
Pages: 2684-2691
Publication/Series: Diabetes Care
Volume: 33
Issue: 12
Document type: Journal article
Publisher: American Diabetes Association

Abstract english

OBJECTIVE - Whole-grain foods are touted for multiple health benefits including enhancing insulin sensitivity and reducing type 2 diabetes risk Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin RESEARCH DESIGN AND METHODS - Via meta-analysis of data from 14 cohorts comprising similar to 48 000 participants of European descent we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations For tests of interaction we considered a P value <0 0028 (0 05 of 18 tests) as statistically significant RESULTS - Greater whole grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics other dietary and lifestyle factors, and BMI (beta [95% Cl] per 1-serving greater whole grain intake -0 009 mmol/l glucose [-0 013 to -0 0051 P < 0 0001 and -0011 pmol/l [In] insulin [-0 015 to -0 0071 P = 0 0003) No interactions met our multiple testing adjusted statistical significance threshold The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0 006) where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin raising allele


  • Endocrinology and Diabetes


  • Nutrition Epidemiology
  • ISSN: 1935-5548
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

Associate senior lecturer

Nutrition Epidemiology

+46 40 39 13 25

+46 73 700 71 45


Jan Waldenströms gata 35, CRC 60:13, Malmö


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