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Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort

  • Emily Sonestedt
  • Ulrika Ericson
  • Bo Gullberg
  • JL Penalvo
  • H Adlercreutz
  • Elisabet Wirfält
Publishing year: 2008
Language: English
Pages: 1005-1009
Publication/Series: European Journal of Clinical Nutrition
Volume: 62
Issue: 8
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

Objectives:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods:Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results:The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 (95% CI, 0.22-0.72) for non-fasting samples.Conclusions:Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.European Journal of Clinical Nutrition advance online publication, 30 May 2007; doi:10.1038/sj.ejcn.1602811.


  • Nutrition and Dietetics


  • Nutrition Epidemiology
  • ISSN: 1476-5640
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

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Nutrition Epidemiology

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