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Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.

  • Emily Sonestedt
  • Charlotta Roos
  • Bo Gullberg
  • Ulrika Ericson
  • Elisabet Wirfält
  • Marju Orho-Melander
Publishing year: 2009
Language: English
Pages: 1418-1425
Publication/Series: The American journal of clinical nutrition
Volume: 90
Document type: Journal article
Publisher: American Society for Clinical Nutrition

Abstract english

BACKGROUND: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation. OBJECTIVE: The aim was to examine whether dietary factors (macronutrient and fiber intakes) and leisure-time physical activity modify the association between genetic variation in FTO and body mass index (BMI; in kg/m(2)). DESIGN: A cross-sectional study examined 4839 subjects in the population-based Malmö Diet and Cancer study with dietary data (from a modified diet history method) and information on the genetic variant FTO (rs9939609). Direct anthropometric measures were made, and leisure-time physical activity was determined from the duration participants spent on 18 different physical activities. RESULTS: Significant interactions between energy-adjusted fat intake and FTO genotype (P = 0.04) and between carbohydrate intake and FTO genotype (P = 0.001) on BMI were observed. The observed increase in BMI across FTO genotypes was restricted to those who reported a high-fat diet, with a mean BMI of 25.3 (95% CI: 24.9, 25.6) among TT carriers and of 26.3 (95% CI: 25.8, 26.8) among AA carriers (P = 0.0001). The FTO variant was not associated with a higher BMI among subjects with lower fat intakes (BMI = 25.7 and 25.9 in TT carriers and AA carriers, respectively; P = 0.42). Among individuals with a low-carbohydrate intake, we observed a mean BMI of 25.4 for TT carriers and of 26.8 for AA carriers. The increase in BMI across genotypes was mainly restricted to individuals who reported low leisure-time physical activity (P for trend = 0.004, P for interaction = 0.05). CONCLUSION: Our results indicate that high-fat diets and low physical activity levels may accentuate the susceptibility to obesity by the FTO variant.


  • Nutrition and Dietetics


  • Nutrition Epidemiology
  • Genomics, Diabetes and Endocrinology
  • ISSN: 1938-3207
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

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Nutrition Epidemiology

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