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TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.

  • Isabel Drake
  • Peter Wallström
  • George Hindy
  • Ulrika Ericson
  • Bo Gullberg
  • Anders Bjartell
  • Emily Sonestedt
  • Marju Orho-Melander
  • Elisabet Wirfält
Publishing year: 2014
Language: English
Pages: 1161-1170
Publication/Series: The Prostate
Volume: 74
Issue: 12
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.


  • Obstetrics, Gynecology and Reproductive Medicine


  • Nutrition Epidemiology
  • Diabetes - Cardiovascular Disease
  • Urological cancer, Malmö
  • ISSN: 0270-4137
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

Associate senior lecturer

Nutrition Epidemiology

+46 40 39 13 25

+46 73 700 71 45


Jan Waldenströms gata 35, CRC 60:13, Malmö


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Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00