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Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

  • Mireia Obón-Santacana
  • Leila Luján-Barroso
  • Heinz Freisling
  • Sabine Naudin
  • Marie Christine Boutron-Ruault
  • Francesca Romana Mancini
  • Vinciane Rebours
  • Tilman Kühn
  • Verena Katzke
  • Heiner Boeing
  • Anne Tjønneland
  • Anja Olsen
  • Kim Overvad
  • Cristina Lasheras
  • Miguel Rodríguez-Barranco
  • Pilar Amiano
  • Carmen Santiuste
  • Eva Ardanaz
  • Kay Thee Khaw
  • Nicholas J. Wareham
  • Julie A. Schmidt
  • Dagfinn Aune
  • Antonia Trichopoulou
  • Paschalis Thriskos
  • Eleni Peppa
  • Giovanna Masala
  • Sara Grioni
  • Rosario Tumino
  • Salvatore Panico
  • Bas Bueno-de-Mesquita
  • Veronica Sciannameo
  • Roel Vermeulen
  • Emily Sonestedt
  • Malin Sund
  • Elisabete Weiderpass
  • Guri Skeie
  • Carlos A. González
  • Elio Riboli
  • Eric J. Duell
Publishing year: 2020
Language: English
Pages: 76-84
Publication/Series: International Journal of Cancer
Volume: 146
Issue: 1
Document type: Journal article
Publisher: John Wiley and Sons Inc.

Abstract english

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.


  • Cancer and Oncology
  • Nutrition and Dietetics
  • diet
  • EPIC
  • intake
  • nuts
  • pancreatic cancer
  • prospective cohort study
  • seeds


  • Nutrition Epidemiology
  • ISSN: 0020-7136
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

Associate senior lecturer

Nutrition Epidemiology

+46 40 39 13 25

+46 73 700 71 45


Jan Waldenströms gata 35, CRC 60:13, Malmö


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Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00