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High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort

  • Ulrika Ericson
  • Emily Sonestedt
  • Bo Gullberg
  • Håkan Olsson
  • Elisabet Wirfält
Publishing year: 2007-08
Language: English
Pages: 43-434
Publication/Series: American Journal of Clinical Nutrition
Volume: 86
Issue: 2
Document type: Journal article
Publisher: American Society for Clinical Nutrition

Abstract english

BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.

OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.

DESIGN: This prospective study included all women aged >or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).

RESULTS: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01).

CONCLUSION: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.


  • Nutrition and Dietetics
  • Aged
  • Alcohol Drinking
  • Breast Neoplasms
  • Cohort Studies
  • Female
  • Folic Acid
  • Humans
  • Incidence
  • Leisure Activities
  • Middle Aged
  • Neoplasm Invasiveness
  • Postmenopause
  • Proportional Hazards Models
  • Smoking
  • Socioeconomic Factors
  • Sweden


  • Diabetes - Cardiovascular Disease
  • Nutrition Epidemiology
  • Lund Melanoma Study Group
  • ISSN: 0002-9165
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

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Nutrition Epidemiology

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