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Dietary Folate Intake and Breast Cancer Risk: European Prospective Investigation Into Cancer and Nutrition

Author:
  • J. de Batlle
  • P. Ferrari
  • V. Chajes
  • J. Y. Park
  • N. Slimani
  • F. McKenzie
  • K. Overvad
  • N. Roswall
  • A. Tjonneland
  • M. C. Boutron-Ruault
  • F. Clavel-Chapelon
  • G. Fagherazzi
  • V. Katzke
  • R. Kaaks
  • M. M. Bergmann
  • A. Trichopoulou
  • P. Lagiou
  • D. Trichopoulos
  • D. Palli
  • S. Sieri
  • S. Panico
  • R. Tumino
  • P. Vineis
  • H. B. Bueno-de-Mesquita
  • P. H. Peeters
  • A. Hjartaker
  • D. Engeset
  • E. Weiderpass
  • S. Sanchez
  • N. Travier
  • M. J. Sanchez
  • P. Amiano
  • M. D. Chirlaque
  • A. Barricarte Gurrea
  • K. T. Khaw
  • T. J. Key
  • K. E. Bradbury
  • Ulrika Ericson
  • Emily Sonestedt
  • B. Van Guelpen
  • J. Schneede
  • E. Riboli
  • I. Romieu
Publishing year: 2015
Language: English
Pages: 367-367
Publication/Series: Journal of the National Cancer Institute
Volume: 107
Issue: 1
Document type: Journal article
Publisher: Oxford University Press

Abstract english

There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. During a median follow-up of 11.5 years, 11575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, P (trend) = .037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, P (trend) = .042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, P (trend) = .021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (> 12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, P (interaction) = .035). Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.

Keywords

  • Cancer and Oncology

Other

Published
  • Nutrition Epidemiology
  • ISSN: 1460-2105
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

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Nutrition Epidemiology

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