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Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

Author:
  • Sabine Rohrmann
  • Jakob Linseisen
  • Kim Overvad
  • Anne Mette Lund Wurtz
  • Nina Roswall
  • Anne Tjonneland
  • Marie-Christine Boutron-Ruault
  • Antoine Racine
  • Nadia Bastide
  • Domenico Palli
  • Claudia Agnoli
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • Steffen Weikert
  • Annika Steffen
  • Tilman Kuehn
  • Kuanrong Li
  • Kay-Tee Khaw
  • Nicholas J. Wareham
  • Kathryn E. Bradbury
  • Eleni Peppa
  • Antonia Trichopoulou
  • Dimitrios Trichopoulos
  • H. Bas Bueno-de-Mesquita
  • Petra H. M. Peeters
  • Anette Hjartaker
  • Guri Skeie
  • Elisabete Weiderpass
  • Paula Jakszyn
  • Miren Dorronsoro
  • Aurelio Barricarte
  • Carmen Santiuste de Pablos
  • Esther Molina-Montes
  • Ramon Alonso de la Torre
  • Ulrika Ericson
  • Emily Sonestedt
  • Mattias Johansson
  • Borje Ljungberg
  • Heinz Freisling
  • Isabelle Romieu
  • Amanda J. Cross
  • Anne-Claire Vergnaud
  • Elio Riboli
  • Heiner Boeing
Publishing year: 2015
Language: English
Pages: 423-431
Publication/Series: International Journal of Cancer
Volume: 136
Issue: 5
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR=1.36, 95% CI 1.14-1.62; calibrated, per 50 g/day) and processed meat (HR=1.78, 95% CI 1.05-3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction=0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear. What's new? Kidney cancer strikes different populations with different frequency, with developed nations seeing more cases. In this paper, the authors investigate whether certain elements of diet might correlate with increased incidence of renal cell carcinoma. Using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assessed the amount of meat and fish consumed in populations representing a wide range of dietary habits. They then correlated this data with renal cell carcinoma incidence. They found no effect from eating fish; consuming red and processed meats did increase risk in women, but not in men.

Keywords

  • Cancer and Oncology
  • renal cell cancer
  • cohort study
  • red meat
  • processed meat

Other

Published
  • Diabetes - Cardiovascular Disease
  • ISSN: 0020-7136
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

Associate senior lecturer

Nutrition Epidemiology

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Jan Waldenströms gata 35, CRC 60:13, Malmö

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