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Dietary Fat Intake and Development of Specific Breast Cancer Subtypes.

Author:
  • Sabina Sieri
  • Paolo Chiodini
  • Claudia Agnoli
  • Valeria Pala
  • Franco Berrino
  • Antonia Trichopoulou
  • Vassiliki Benetou
  • Effie Vasilopoulou
  • María-José Sánchez
  • Maria-Dolores Chirlaque
  • Pilar Amiano
  • J Ramón Quirós
  • Eva Ardanaz
  • Genevieve Buckland
  • Giovanna Masala
  • Salvatore Panico
  • Sara Grioni
  • Carlotta Sacerdote
  • Rosario Tumino
  • Marie-Christine Boutron-Ruault
  • Françoise Clavel-Chapelon
  • Guy Fagherazzi
  • Petra H M Peeters
  • Carla H van Gils
  • H Bas Bueno-de-Mesquita
  • Henk J van Kranen
  • Timothy J Key
  • Ruth C Travis
  • Kay Tee Khaw
  • Nicholas J Wareham
  • Rudolf Kaaks
  • Annekatrin Lukanova
  • Heiner Boeing
  • Madlen Schütze
  • Emily Sonestedt
  • Elisabet Wirfält
  • Malin Sund
  • Anne Andersson
  • Veronique Chajes
  • Sabina Rinaldi
  • Isabelle Romieu
  • Elisabete Weiderpass
  • Guri Skeie
  • Engeset Dagrun
  • Anne Tjønneland
  • Jytte Halkjær
  • Kim Overvard
  • Melissa A Merritt
  • David Cox
  • Elio Riboli
  • Vittorio Krogh
Publishing year: 2014
Language: English
Pages: 068-068
Publication/Series: Journal of the National Cancer Institute
Volume: 106
Issue: 5
Document type: Journal article
Publisher: Oxford University Press

Abstract english

We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

Keywords

  • Cancer and Oncology

Other

Published
  • Nutrition Epidemiology
  • Diabetes - Cardiovascular Disease
  • ISSN: 1460-2105
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

Associate senior lecturer

Nutrition Epidemiology

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