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Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C

  • Sophie Hellstrand
  • Emily Sonestedt
  • Ulrika Ericson
  • Bo Gullberg
  • Elisabet Wirfält
  • Bo Hedblad
  • Marju Orho-Melander
Publishing year: 2012
Language: English
Pages: 1183-1189
Publication/Series: Journal of Lipid Research
Volume: 53
Issue: 6
Document type: Journal article
Publisher: American Society for Biochemistry and Molecular Biology

Abstract english

Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T>C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years) from the Swedish population-based Malmo Diet and Cancer cohort. Dietary intakes were assessed by a modified diet history method including 7-day registration of cooked meals. The C-allele of rs174547 was associated with lower LDL concentration (P = 0.03). We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P < 0.001). In addition, significant interaction was observed between rs174547 and the ratio of ALA and linoleic FA intakes on HDL (P = 0.03). However, no significant associations between the C-allele and HDL were detected within the intake tertiles of the ratio. Our findings suggest that dietary intake levels of different PUFAs modify the associated effect of genetic variation in FADS on LDL and HDL.-Hellstrand, S., E. Sonestedt, U. Ericson, B. Gullberg, E. Wirfalt, B. Hedblad, and M. Orho-Melander. Intake levels of dietary PUFAs modify the association between genetic variation in FADS and LDL-C. J. Lipid Res. 2012. 53: 1183-1189.


  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics
  • diet
  • fatty acid desaturase
  • polyunsaturated fatty acids
  • cholesterol
  • cohort
  • epidemiology
  • low density lipoprotein cholesterol


  • Diabetes - Cardiovascular Disease
  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology
  • ISSN: 1539-7262
Emily Sonestedt
E-mail: emily [dot] sonestedt [at] med [dot] lu [dot] se

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Nutrition Epidemiology

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