
Efraim Westholm
Research student

Current project
Mechanisms and signaling pathways underlying development of cystic fibrosis related diabetes.
It is theorized the paracrine signals from the exocrine pancreas leads to alpha- and beta cell failure in CF patients and diabeetes development. This project wills tudy the effects of exosomal microRNA from the exocrine pancreas on endocrine cells and mechanisms through which beta cells dysfunction can occur.
Background
Efraim has medical degree from Lund University as well as a Master thesis project on microRNA-205-5p conducted at German Institute for Human Nutrition Potsdam. Efraim also has technical experience with the patch clamp technique from the Islet Cell Exocytosis group.
Publications
Displaying of publications. Sorted by year, then title.
Interleukin-4 reduces insulin secretion in human islets from healthy but not type-2 diabetic donors
Efraim Westholm, Anna Edlund, Alexandros Karagiannopoulos, Anna Wendt, Lena Eliasson
(2023) Biochemical and Biophysical Research Communications, 649 p.87-92
Journal articleHuman Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
Jones Ofori, Alexandros Karagiannopoulos, Mototsugu Nagao, Efraim Westholm, Shaima Ramadan, et al.
(2022) Diabetes, 71 p.275-284
Journal articleMiR-205 is up-regulated in islets of diabetes-susceptible mice and targets the diabetes gene Tcf7l2
Meriem Ouni, Pascal Gottmann, Efraim Westholm, Kristin Schwerbel, Markus Jähnert, et al.
(2021) Acta Physiologica, 232
Journal articleIslet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus
Efraim Westholm, Anna Wendt, Lena Eliasson
(2021) Clinical Medicine Insights: Endocrinology and Diabetes, 14 p.1-7
Journal article review