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Eero Lindholm

Associate professor

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Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy.

Author

  • Eero Lindholm
  • Mia Klannemark
  • Elisabet Agardh
  • Leif Groop
  • Carl-David Agardh

Summary, in English

Increased production of reactive oxygen species (ROS) has been suggested as a cause of diabetic complications. Uncoupling proteins (UCPs) have been ascribed a role in reducing the formation of ROS, and genetic variation in genes encoding for UCPs could thus be putative candidate genes for diabetic nephropathy. To test this hypothesis we searched for association between the A→G (−3862) variant in UCP1, the insertion/deletion (I/D) polymorphism in exon 8 in UCP2, and the C→T (−55) polymorphism in UCP3 and diabetic nephropathy in 218 diabetic patients with normal urinary albumin excretion rate (AER), 216 with micro- or macroalbuminuria, and in 106 control subjects without a family history of diabetes. We did not find any association between the different polymorphisms and diabetic nephropathy, nor did we observe any difference in AER among carriers of different UCP1–3 genotypes. We could, however, confirm the reported association between BMI and the UCP3 −55 C→T polymorphism; patients carrying the T allele had higher BMI than patients homozygous for the C allele (26.4±4.2 vs. 25.3±4.3 kg/m2; P=.01). We conclude that studied polymorphisms in the UCP1–3 genes do not play a major role in the development of micro- or macroalbuminuria in Scandinavian diabetic patients.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Department of Clinical Sciences, Malmö
  • Ophthalmology (Malmö)

Publishing year

2004

Language

English

Pages

103-107

Publication/Series

Journal of Diabetes and its Complications

Volume

18

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • Uncoupling proteins
  • Diabetes mellitus
  • Microalbuminuria
  • Polymorphisms

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Ophthalmology (Malmö)

ISBN/ISSN/Other

  • ISSN: 1873-460X