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David Nicholls

Visiting research fellow

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Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals

Author

  • David Nicholls

Summary, in English

Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated.

Department/s

  • Department of Experimental Medical Science
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2010

Language

English

Pages

457-459

Publication/Series

Biochemical Society Transactions

Volume

38

Document type

Conference paper

Publisher

Portland Press

Topic

  • Biochemistry and Molecular Biology

Keywords

  • exocytosis
  • brain
  • potassium channel
  • glutamate
  • synaptosome

Conference name

Conference on Synaptopathies - Dysfunction of Synaptic Function

Conference date

2009-09-02 - 2009-09-04

Status

Published

ISBN/ISSN/Other

  • ISSN: 1470-8752
  • ISSN: 0300-5127