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David Nicholls

Visiting research fellow

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Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

Author

  • Lotta Andersson
  • Berengere Valtat
  • Annika Bagge
  • Vladimir Sharoyko
  • David Nicholls
  • Philippe Ravassard
  • Raphael Scharfmann
  • Peter Spégel
  • Hindrik Mulder

Summary, in English

Studies on beta cell metabolism are often conducted in rodent beta cell lines due to the lack of stable human beta cell lines. Recently, a human cell line, EndoC-βH1, was generated. Here we investigate stimulus-secretion coupling in this cell line, and compare it with that in the rat beta cell line, INS-1 832/13, and human islets.

Department/s

  • Diabetes - Molecular Metabolism
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2015

Language

English

Publication/Series

PLoS ONE

Volume

10

Issue

3

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Molecular Metabolism
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1932-6203