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David Nicholls

Visiting research fellow

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Spare respiratory capacity, oxidative stress and excitotoxicity

Author

  • David Nicholls

Summary, in English

Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. mitochondria play a central role in the survival or death of the exposed neuron. calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.

Department/s

  • Department of Experimental Medical Science

Publishing year

2009

Language

English

Pages

1385-1388

Publication/Series

Biochemical Society Transactions

Volume

37

Document type

Journal article

Publisher

Biochemical Society

Topic

  • Biochemistry and Molecular Biology

Keywords

  • oxidative
  • mitochondrion
  • ischaemia
  • glutamate
  • ATP
  • excitotoxicity
  • stress

Status

Published

ISBN/ISSN/Other

  • ISSN: 0300-5127