Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

David Nicholls

Visiting research fellow

Default user image.

Mitochondrial ion circuits.

Author

  • David Nicholls

Summary, in English

Proton circuits across the inner mitochondrial membrane link the primary energy generators, namely the complexes of the electron transport chain, to multiple energy utilizing processes, including the ATP synthase, inherent proton leak pathways, metabolite transport and linked circuits of sodium and calcium. These mitochondrial circuits can be monitored in both isolated preparations and intact cells and, for the primary proton circuit techniques, exist to follow both the proton current and proton electrochemical potential components of the circuit in parallel experiments, providing a quantitative means of assessing mitochondrial function and, equally importantly, dysfunction.

Department/s

  • Department of Experimental Medical Science
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2010

Language

English

Pages

25-35

Publication/Series

Essays in Biochemistry

Volume

47

Document type

Journal article

Publisher

Portland Press

Topic

  • Neurosciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 0071-1365