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ludc web

Daowei Yang

Postdoctoral fellow

ludc web

Bcl-2 hijacks the arsenic trioxide resistance in SH-SY5Y cells

Author

  • Jinling Wang
  • Xiaohui Peng
  • Daowei Yang
  • Mengyu Guo
  • Xiao Xu
  • Fengyue Yin
  • Yu Wang
  • Jiaqing Huang
  • Linghui Zhan
  • Zhongquan Qi

Summary, in English

Aresenic trioxide (ATO) is proven to be active against leukaemia cells by inducing apoptosis and differentiation. Even though ATO could effectively induce remissions of leukaemia cells, the drug resistance was observed occasionally. To further dissect the mechanism of ATO resistance, we selected the ATO-resistant SH-SY5Y cells and found that Bcl-2 controlled the sensitivity of ATO in SH-SY5Y cells. We report that necroptosis, autophagy, NF-ƘB and MAPK signalling pathway are not involved in ATO-induced apoptosis. Moreover, the ATO-resistant cells showed distinct mitochondrial morphology compared with that of ATO-sensitive cells. Intriguingly, nude mice-bearing ATO-sensitive cells derived xenograft tumours are more sensitive to ATO treatment compared with that of ATO-resistant cells. These data demonstrate that cancer cells can acquire the ATO-resistance ability by increasing the Bcl-2 expression.

Department/s

  • Diabetes - Islet Patophysiology
  • NanoLund: Center for Nanoscience
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2022

Language

English

Pages

563-569

Publication/Series

Journal of Cellular and Molecular Medicine

Volume

26

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cancer and Oncology

Status

Published

Research group

  • Diabetes - Islet Patophysiology

ISBN/ISSN/Other

  • ISSN: 1582-1838