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Daniel Engelbertsen

Assistant researcher

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Innate lymphoid cells in atherosclerosis

Author

  • Daniel Engelbertsen
  • Andrew H Lichtman

Summary, in English

The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions.

Publishing year

2017-12-05

Language

English

Pages

32-36

Publication/Series

European Journal of Pharmacology

Volume

816

Document type

Journal article review

Publisher

Elsevier

Keywords

  • Animals
  • Atherosclerosis/immunology
  • Humans
  • Immunity, Innate
  • Lymphocytes/cytology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1879-0712