Big data and complex traits: a smorgasbord of opportunities and applications
Speaker: Professor Peter Visscher, program in complex trait genomics, Queensland, Brain Institute, University of Queensland, Brisbane, Australia
Host: Paul Franks
Visscher’s key works include the development and application of methods to estimate SNP-based heritability 1,2,3, genetic architecture3, and gene-environment interactions4,5 in complex traits, amongst other major contributions.
- Yang J, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet. 2011 Jan 7;88(1):76-82.
- Yang J, Zeng J, Goddard ME, Wray NR, Visscher PM. Concepts, estimation and interpretation of SNP-based heritability. Nat Genet. 2017 Aug 30;49(9):1304-1310
- Yang J, et al. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nat Genet. 2015 Oct;47(10):1114-20.
- Yang J, et al. FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012 Oct 11;490(7419):267-72
Robinson MR, et al. Genotype-covariate interaction effects and the heritability of adult body mass index. Nat Genet. 2017 Aug;49(8):1174-1181