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Corrado Cilio

Professor

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Inflammation at birth and the insulin-like growth factor system in very preterm infants.

Author

  • Ingrid Pupp
  • Lena Hellström-Westas
  • Corrado Cilio
  • S Andersson
  • Vineta Fellman
  • David Ley

Summary, in English

Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in cord blood and neonatal blood at 72 h after delivery were analysed in relation to levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed separately according to birth weight for GA. Results: In cord blood of infants appropriate for gestational age (AGA) higher levels of IL-6 and IL-8 were associated with lower IGF-I (r = -0.38, p = 0.008 and r = -0.36, p = 0.014). Higher levels of IL-6, IL-8 and TNF-alpha were associated with both higher levels of lpIGFBP-1 (r = 0.54, p < 0.001, r = 0.50, p < 0.001 and r = 0.13, p = 0.012, respectively) and hpIGFBP-1 (r = 0.55, p < 0.001, r = 0.45, p = 0.002 and r = 0.32, p = 0.026, respectively). Infants with intraventricular haemorrhage grade III (n = 5) had higher levels of lp/hpIGFBP-1 in cord blood (p = 0.001 and 0.002, respectively). Conclusion: Pro-inflammation at birth is associated with changes in the IGF-system. This may be of importance for development of brain damage in preterm infants.

Department/s

  • Paediatrics (Lund)
  • Diabetes - Immunovirology

Publishing year

2007

Language

English

Pages

830-836

Publication/Series

Acta Pædiatrica

Volume

96

Issue

6

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Pediatrics

Keywords

  • foetal inflammation
  • insulin-like growth factor
  • brain damage
  • cytokine
  • I
  • preterm

Status

Published

Research group

  • Diabetes - Immunovirology

ISBN/ISSN/Other

  • ISSN: 1651-2227