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Corrado Cilio

Professor

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Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates

Author

  • Suresh Kumar Mendu
  • Lina Åkesson
  • Zhe Jin
  • Anna Edlund
  • Corrado Cilio
  • Åke Lernmark
  • Bryndis Birnira

Summary, in English

GABA (gamma-aminobutyric acid), the main inhibitory neurotransmitter in the central nervous system is also present in the pancreatic islet beta cells where it may function as a paracrine molecule and perhaps as an immunomodulator of lymphocytes infiltrating the pancreatic islet. We examined CD4(+) and CD8(+) T cells from diabetes prone (DRlyp/lyp) or resistant (DR+/+) congenic biobreeding (BB) rats for expression of GABA(A) channels. Our results show that BB rat CD4(+) and CD8(+) T cells express alpha 1, alpha 2, alpha 3, alpha 4, alpha 6, beta 3, gamma 1, delta, rho 1 and rho 2 CABA(A) channel subunits. In CD8(+) T cells from DRlyp/lyp animals the subunits were significantly upregulated relative to expression levels in the CD8+ T cells from DR+/+ rats as well as from CD4(+) T cells from both DRlyp/lyp and DR+/+ rats. Functional channels were formed in the T cells and physiological concentrations of GABA (100 nM) decreased T cell proliferation. Our results are consistent with the hypothesis that GABA in the islets of Langerhans may diminish inflammation by inhibition of activated T lymphocytes. (C) 2010 Elsevier Ltd. All rights reserved.

Department/s

  • Department of Clinical Sciences, Malmö
  • Diabetes and Celiac Unit
  • Diabetes - Islet Cell Exocytosis
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2011

Language

English

Pages

399-407

Publication/Series

Molecular Immunology

Volume

48

Issue

4

Document type

Journal article

Publisher

Pergamon Press Ltd.

Topic

  • Immunology in the medical area

Keywords

  • GABA
  • Diabetes
  • Lymphocytes
  • GABA(A) subunits
  • Proliferation
  • Immunomodulation

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Diabetes - Islet Cell Exocytosis

ISBN/ISSN/Other

  • ISSN: 1872-9142