Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Corrado Cilio

Professor

Default user image.

Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.

Author

  • Jonathan Esguerra
  • Caroline Bolmeson
  • Corrado Cilio
  • Lena Eliasson

Summary, in English

The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.

Department/s

  • Diabetes - Islet Cell Exocytosis
  • Create Health
  • Evolutionary ecology
  • Diabetes - Immunovirology
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2011

Language

English

Publication/Series

PLoS ONE

Volume

6

Issue

4

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Endocrinology and Diabetes

Keywords

  • Islets of Langerhans/*drug effects/*metabolism
  • MicroRNAs/*genetics
  • Glucose/*pharmacology
  • Gene Expression Profiling
  • Animals
  • Type 2/*metabolism
  • Diabetes Mellitus
  • Polymerase Chain Reaction
  • Rats
  • Wistar

Status

Published

Research group

  • Diabetes - Islet Cell Exocytosis
  • Diabetes - Immunovirology

ISBN/ISSN/Other

  • ISSN: 1932-6203