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Corrado Cilio

Professor

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Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells.

Author

  • Hojjatollah NozadCharoudeh
  • Yan-Juan Tang
  • Min Cheng
  • Corrado Cilio
  • Sten Eirik W Jacobsen
  • Ewa Sitnicka Quinn

Summary, in English

Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. (Blood. 2010; 116(2): 183-192)

Department/s

  • Lymphoid Development and Regulation
  • Stem Cell Center
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Diabetes - Immunovirology
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy

Publishing year

2010

Language

English

Pages

183-192

Publication/Series

Blood

Volume

116

Issue

2

Document type

Journal article

Publisher

American Society of Hematology

Topic

  • Hematology

Status

Published

Research group

  • Lymphoid Development and Regulation
  • Diabetes - Immunovirology

ISBN/ISSN/Other

  • ISSN: 1528-0020