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Corrado Cilio

Professor

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Genetic and perinatal factors as risk for childhood type 1 diabetes

Author

  • K Larsson
  • Helena Larsson
  • E Cederwall
  • K Kockum
  • Sture Sjöblad
  • Bengt Lindberg
  • Barbro Lernmark
  • Corrado Cilio
  • Sten Ivarsson
  • Åke Lernmark

Summary, in English

The mechanisms by which gestational infections, blood incompatibility, birth weight, mother's age and other prenatal or neonatal events increase the risk for type 1 diabetes are not understood. Studies so far have been retrospective, and there is a lack of population-based prospective studies. The possibility identifying children at type 1 diabetes risk among first-degree relatives has resulted in prospective studies aimed at identifying postnatal events associated with the appearance of autoantibody markers for type 1 diabetes and a possible later onset of diabetes. However, the majority (85%) of new onset type 1 diabetes children do not have a first-degree relative with the disease. Population-based studies are therefore designed to prospectively analyse pregnant mothers and their offspring. One such study is DiPiS (Diabetes Prediction in Skane), which is examining a total of about 10 000 pregnancies expected every year in the Skane (Scania) region of Sweden that has 1.1 million inhabitants. Blood samples from all mothers in this region are obtained during pregnancy and at the time of delivery. Cord blood is analysed for HLA high-risk alleles and for autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GADA), the protein tyrosine phosphatase-related IA-2 antigen (IA-2A) and insulin (IAA) as a measure of prenatal autoimmune exposure. Identifying high-risk children by genetic, autoimmune and gestational risk factors followed by prospective analyses will make it possible to test the hypothesis that gestational events may trigger beta cell autoimmunity as a prerequisite for childhood type 1 diabetes. Copyright (C) 2004 John Wiley Sons, Ltd.

Department/s

  • Paediatric Endocrinology
  • Neonatology
  • Paediatrics (Lund)
  • Department of Clinical Sciences, Malmö

Publishing year

2004

Language

English

Pages

429-437

Publication/Series

Diabetes/Metabolism Research & Reviews

Volume

20

Issue

6

Document type

Journal article review

Publisher

John Wiley and Sons

Topic

  • Endocrinology and Diabetes

Keywords

  • transplacental transfer
  • gestational infections
  • HLA
  • autoimmunity
  • islet autoantibodies
  • blood incompatibility

Status

Published

Research group

  • Paediatric Endocrinology
  • Neonatology

ISBN/ISSN/Other

  • ISSN: 1520-7552