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ludc web

Claire Lyons

Assistant researcher

ludc web

Serotonergic Regulation of Insulin Secretion

Author

  • Luis Rodrigo Cataldo Bascuñan
  • Claire Lyons
  • Hedvig Bennet
  • Isabella Artner
  • Malin Fex

Summary, in English

The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islets, and receptor independent mechanisms in insulin producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing. It is now widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main cause of Type 2 Diabetes (T2D), an ongoing global epidemic. In this context, 5-HT signaling may be of importance. In fact, 5-HT may serve an essential role in regulating the release of insulin and glucagon, the two main hormones that control glucose and lipid homeostasis. In the present review, we will discuss past and current understanding of 5-HT's role in the endocrine pancreas. This article is protected by copyright. All rights reserved.

Department/s

  • Endocrine Cell Differentiation and Function
  • Stem Cell Center
  • Diabetes - Molecular Metabolism
  • Diabetes and Celiac Unit
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2019-01

Language

English

Publication/Series

Acta Physiologica

Volume

225

Issue

1

Document type

Journal article review

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Endocrine Cell Differentiation and Function
  • Diabetes - Molecular Metabolism
  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 1748-1716