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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

Pharmacoepigenetics in type 2 diabetes : is it clinically relevant?

Author

  • Charlotte Ling

Summary, in English

Data generated over nearly two decades clearly demonstrate the importance of epigenetic modifications and mechanisms in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is less well established. The field of pharmacoepigenetics covers epigenetic biomarkers that predict response to therapy, therapy-induced epigenetic alterations as well as epigenetic therapies including inhibitors of epigenetic enzymes. Not all individuals with type 2 diabetes respond to glucose-lowering therapies in the same way, and there is therefore a need for clinically useful biomarkers that discriminate responders from non-responders. Blood-based epigenetic biomarkers may be useful for this purpose. There is also a need for a better understanding of whether existing glucose-lowering therapies exert their function partly through therapy-induced epigenetic alterations. Finally, epigenetic enzymes may be drug targets for type 2 diabetes. Here, I discuss whether pharmacoepigenetics is clinically relevant for type 2 diabetes based on studies addressing this topic.

Department/s

  • Diabetes - Epigenetics
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2022

Language

English

Publication/Series

Diabetologia

Document type

Journal article (comment)

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Keywords

  • Adipose tissue
  • Beta cells
  • Blood
  • Blood-based epigenetic biomarkers
  • DNA methylation
  • Drug targets
  • Epigenetic enzymes
  • Epigenetics
  • Histone modification
  • Inhibitors
  • Liver
  • Non-coding RNA
  • Pancreatic islets
  • Pharmacogenetics
  • Precision medicine
  • Skeletal muscle

Status

Epub

Research group

  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 0012-186X