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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Author

  • Oliver Kluth
  • Mandy Stadion
  • Pascal Gottmann
  • Heja Aga
  • Markus Jähnert
  • Stephan Scherneck
  • Heike Vogel
  • Ulrika Krus
  • Anett Seelig
  • Charlotte Ling
  • Jantje Gerdes
  • Annette Schürmann
Show all

Summary, in English

Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Diabetes - Islet Patophysiology
  • Diabetes - Epigenetics

Publishing year

2019

Language

English

Pages

3-3036

Publication/Series

Cell Reports

Volume

26

Issue

11

Document type

Journal article

Publisher

Cell Press

Topic

  • Medical Genetics
  • Endocrinology and Diabetes

Keywords

  • beta-cell proliferation
  • cilia genes
  • human pancreatic islets
  • islet transcriptomics
  • New Zealand Obese mouse
  • pathway enrichment analysis
  • primary cilia
  • type 2 diabetes

Status

Published

Research group

  • Diabetes - Islet Patophysiology
  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 2211-1247