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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.

Author

  • Emma A Nilsson
  • Ashok Matte
  • Alexander Perfilyev
  • Vanessa D de Mello
  • Pirjo Käkelä
  • Jussi Pihlajamäki
  • Charlotte Ling

Summary, in English

Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.

Department/s

  • Diabetes - Epigenetics
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2015

Language

English

Pages

1491-1501

Publication/Series

Journal of Clinical Endocrinology and Metabolism

Volume

100

Issue

11

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 1945-7197