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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Author

  • Elisabet Agardh
  • Annika Lundstig
  • Alexander Perfilyev
  • Petr Volkov
  • Tove Freiburghaus
  • Eero Lindholm
  • Tina Rönn
  • Carl-David Agardh
  • Charlotte Ling

Summary, in English

Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).

Department/s

  • Ophthalmology (Malmö)
  • Celiac Disease and Diabetes Unit
  • Diabetes - Epigenetics
  • Genomics, Diabetes and Endocrinology
  • Department of Clinical Sciences, Malmö
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2015

Language

English

Publication/Series

BMC Medicine

Volume

13

Issue

182

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Ophthalmology (Malmö)
  • Diabetes and Celiac Unit
  • Diabetes - Epigenetics
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1741-7015