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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

Developmental programming : State-of-the-science and future directions: Summary from a Pennington Biomedical symposium

Author

  • Elizabeth F Sutton
  • L Anne Gilmore
  • David B Dunger
  • Bas T Heijmans
  • Marie-France Hivert
  • Charlotte Ling
  • J Alfredo Martinez
  • Susan E Ozanne
  • Rebecca A Simmons
  • Moshe Szyf
  • Robert A Waterland
  • Leanne M Redman
  • Eric Ravussin

Summary, in English

OBJECTIVE: On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies.

RESULTS: This symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the developmental programming of health and disease.

CONCLUSIONS: Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure, and the resulting tissue-specific epigenetic signature were extensively discussed and are presented in this meeting summary.

Department/s

  • Diabetes - Epigenetics
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2016-05

Language

English

Pages

1018-1026

Publication/Series

Obesity

Volume

24

Issue

5

Document type

Journal article review

Publisher

Nature Publishing Group

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology

Status

Published

Research group

  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 1930-739X