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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue

Author

  • L Nilsson
  • N Binart
  • M Bohlooly-Y
  • Margareta Bramnert
  • E Egecioglu
  • J Kindblom
  • PA Kelly
  • JJ Kopchick
  • CJ Ormandy
  • Charlotte Ling
  • H Billig

Summary, in English

Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and GH in in vitro cultured human adipose tissue. Furthermore, PRL increased adiponectin receptor 1 (AdipoR1) mRNA expression and GH decreased AdipoR2 expression in the cultured human adipose tissue. In transgenic mice expressing GH, and female mice expressing PRL, serum levels of adiponectin were decreased. In contrast, GH receptor deficient mice had elevated adiponectin levels, while PRL receptor deficient mice were unaffected. In conclusion, we demonstrate gene expression of AdipoR1 and AdipoR2 in human adipose tissue for the first time, and show that these are differentially regulated by PRL and GH. Both PRL and GH reduced adiponectin secretion in human adipose tissue in vitro and in mice in vivo. Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance.

Department/s

  • Department of Clinical Sciences, Malmö
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Epigenetics

Publishing year

2005

Language

English

Pages

1120-1126

Publication/Series

Biochemical and Biophysical Research Communications

Volume

331

Issue

4

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • prolactin
  • adiponectin
  • adiponectin receptor
  • growth hormone

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 1090-2104