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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

Prolactin Suppresses Malonyl-CoA Concentration in Human Adipose Tissue

Author

  • L. A. Nilsson
  • C. Roepstorff
  • B. Kiens
  • H. Billig
  • Charlotte Ling

Summary, in English

Prolactin is best known for its involvement in lactation, where it regulates mechanisms that supply nutrients for milk production. In individuals with pathological hyperprolactinemia, glucose and fat homeostasis have been reported to be negatively influenced. It is not previously known, however, whether prolactin regulates lipogenesis in human adipose tissue. The aim of this study was to investigate the effect of prolactin on lipogenesis in human adipose tissue in vitro. Prolactin decreased the concentration of malonyl-CoA, the product of the first committed step in lipogenesis, to 77+/-6% compared to control 100+/-5% (p=0.022) in cultured human adipose tissue. In addition, prolactin was found to decrease glucose transporter 4 (GLUT4) mRNA expression, which play cause decreased glucose uptake. In conclusion, we propose that prolactin decreases lipogenesis in human adipose tissue as a consequence of suppressed malonyl-CoA concentration in parallel with decreased GLUT-4 expression. In the lactating woman, this regulation in adipose tissue may enhance the provision of nutrients for the infant instead of nutrients being stored in adipose tissue. In hyperprolactinemic individuals, a suppressed lipogenesis could contribute to an insulin resistant state with

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2009

Language

English

Pages

747-751

Publication/Series

Hormone and Metabolic Research

Volume

41

Issue

10

Document type

Journal article

Publisher

Georg Thieme Verlag KG

Topic

  • Endocrinology and Diabetes

Keywords

  • retinol
  • glucose transporter 4
  • lipogenesis
  • acetyl-CoA carboxylase
  • binding protein 4
  • human adipose tissue

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1439-4286