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Charlotte Ling

Charlotte Ling

Professor

Charlotte Ling

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

Author

  • Elin Hall
  • Tasnim Dayeh
  • Clare L Kirkpatrick
  • Claes Wollheim
  • Marloes Dekker Nitert
  • Charlotte Ling

Summary, in English

Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Diabetes - Epigenetics
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2013

Language

English

Publication/Series

BMC Medical Genetics

Volume

14

Issue

Jul,23

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Medical Genetics

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 1471-2350