Charlotte Ling

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K Ofori, et al.
(2023) The Journal of clinical investigation, 133
Journal article

Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Ratika Sehgal, Alexander Perfilyev, Ville Männistö, Jyrki Ågren, Emma Nilsson, et al.
(2023) Clinical Epigenetics, 15
Journal article

Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers

Colette Christiansen, Max Tomlinson, Melissa Eliot, Emma Nilsson, Ricardo Costeira, et al.
(2022) Genome Medicine, 14
Journal article

Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns, Which Associate With Future Diabetic Complications

Silja Schrader, Alexander Perfilyev, Emma Ahlqvist, Leif Groop, Allan Vaag, et al.
(2022) Diabetes Care, 45 p.1621-1630
Journal article

Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine?

Charlotte Ling, Karl Bacos, Tina Rönn
(2022) Nature Reviews Endocrinology, 18 p.433-448
Journal article review

Type 2 diabetes classification : a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort

Diana Hedevang Christensen, Sia K. Nicolaisen, Emma Ahlqvist, Jacob V. Stidsen, Jens Steen Nielsen, et al.
(2022) BMJ Open Diabetes Research and Care, 10
Journal article

Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells

Cristiane Dos Santos, Alexandros Karagiannopoulos, Alex Rafacho, Alexander Perfilyev, Lena Eliasson, et al.
(2022) Life Sciences, 307
Journal article

Pharmacoepigenetics in type 2 diabetes : is it clinically relevant?

Charlotte Ling
(2022) Diabetologia, 65 p.1849-1853
Journal article (comment)

Epigenetic epidemiology and alterations in type 2 diabetes and obesity

Charlotte Ling, Sabrina Ruhrmann, Johanna Säll, Karl Bacos, Tina Rönn
(2022) Epigenetic epidemiology , p.445-474
Book chapter

Ex vivo and in vivo experimental investigation of miR-148a-3p as a novel therapy for insulin secretion and type 2 diabetes

Elaine Cowan, Cheng Luan, Jones Ofori, Alexandros Karagiannopoulos, Jonathan LS Esguerra, et al.
(2022) Diabetologia, 65
Conference paper: abstract

Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes

Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia García-Calzón, Charlotte Ling
(2021) Epigenomics, 13 p.919-925
Journal article

VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

Cajsa Davegårdh, Johanna Säll, Anna Benrick, Christa Broholm, Petr Volkov, et al.
(2021) Nature Communications, 12
Journal article

Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring

Josefine Jönsson, Kristina M. Renault, Sonia García-Calzón, Alexander Perfilyev, Angela C. Estampador, et al.
(2021) Diabetes, 70 p.854-866
Journal article

Excess of glucocorticoids during late gestation impairs the recovery of offspring’s β-cell function after a postnatal injury

Cristiane dos Santos, Alex Rafacho, Sandra Mara Ferreira, Jean Franciesco Vettorazzi, Thiago dos Reis Araújo, et al.
(2021) FASEB Journal, 35
Journal article

Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

Vanessa D. de Mello, Ratika Sehgal, Ville Männistö, Anton Klåvus, Emma A Nilsson, et al.
(2021) Liver International, 41 p.754-763
Journal article

Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes

Emma Nilsson, Magdalena Vavakova, Alexander Perfilyev, Johanna Säll, Per-Anders Jansson, et al.
(2021) Diabetes, 70 p.2402-2418
Journal article

Novel miR-29 mitochondrial-associated gene pathways predicted to regulate beta cell insulin secretion

Elaine Cowan, Jiangming Sun, Jones Ofori, Cheng Luan, Enming Zhang, et al.
(2021) Diabetologia, 64
Conference paper: abstract

Epigenetic regulation of insulin action and secretion – role in the pathogenesis of type 2 diabetes

C. Ling
(2020) Journal of Internal Medicine, 288 p.158-167
Journal article review

Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

Christa Broholm, Rasmus Ribel-Madsen, Line Hjort, Anders Henrik Olsson, Juliane Maria Dorothee Ahlers, et al.
(2020) Endocrine Research, 45 p.58-71
Journal article

Electroacupuncture mimics exercise-induced changes in skeletal muscle gene expression in women with polycystic ovary syndrome

Anna Benrick, Nicolas J. Pillon, Emma Nilsson, Eva Lindgren, Anna Krook, et al.
(2020) Journal of Clinical Endocrinology and Metabolism, 105 p.2027-2041
Journal article

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, et al.
(2020) Science Translational Medicine, 12
Journal article

Epigenetic changes in islets of langerhans preceding the onset of diabetes

Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jähnert, Mandy Stadion, et al.
(2020) Diabetes, 69 p.2503-2517
Journal article

Glucolipotoxicity alters insulin secretion via epigenetic changes in human islets

Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, et al.
(2019) Diabetes, 68 p.1965-1974
Journal article

Fasting unmasks differential fat and muscle transcriptional regulation of metabolic gene sets in low versus normal birth weight men

Linn Gillberg, Tina Rönn, Sine Wanda Jørgensen, Alexander Perfilyev, Line Hjort, et al.
(2019) EBioMedicine, 47 p.341-351
Journal article

ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes.

Madhusudhan Bysani, Rasmus Agren, Cajsa Davegårdh, Petr Volkov, Tina Rönn, et al.
(2019) Scientific Reports, 9
Journal article

Liver DNA methylation of FADS2 associates with FADS2 genotypex 06 Biological Sciences 0604 Genetics

Paula Walle, Ville Männistö, Vanessa Derenji De Mello, Maija Vaittinen, Alexander Perfilyev, et al.
(2019) Clinical Epigenetics, 11
Journal article

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

Cajsa Davegårdh, Elin Hall Wedin, Christa Broholm, Tora Ida Henriksen, Maria Pedersen, et al.
(2019) Stem Cell Research and Therapy, 10
Journal article

Epigenetics in Human Obesity and Type 2 Diabetes

Charlotte Ling, Tina Rönn
(2019) Cell Metabolism, 29 p.1028-1044
Journal article review

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Oliver Kluth, Mandy Stadion, Pascal Gottmann, Heja Aga, Markus Jähnert, et al.
(2019) Cell Reports, 26 p.3-3036
Journal article

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, et al.
(2019) Journal of Diabetes Research, 2019
Journal article

Epigenome-wide association study of incident type 2 diabetes in a British population : EPIC-Norfolk study

Alexia Cardona, Felix R. Day, John R.B. Perry, Marie Loh, Audrey Y. Chu, et al.
(2019) Diabetes, 68 p.2315-2326
Journal article

A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome

Milana Kokosar, Anna Benrick, Alexander Perfilyev, Emma Nilsson, Thomas Källman, et al.
(2018) Scientific Reports, 8
Journal article

Transcriptional and Epigenetic Changes Influencing Skeletal Muscle Metabolism in Women With Polycystic Ovary Syndrome

Emma Nilsson, Anna Benrick, Milana Kokosar, Anna Krook, Eva Lindgren, et al.
(2018) The Journal of clinical endocrinology and metabolism, 103 p.4465-4477
Journal article

Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

Line Hjort, David Martino, Louise Groth Grunnet, Haroon Naeem, Jovana Maksimovic, et al.
(2018) JCI Insight, 3
Journal article

MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation

Mahboubeh Daneshpajooh, Lena Eliasson, Karl Bacos, Charlotte Ling
(2018) Acta Diabetologica, 55 p.1231-1235
Journal article

DNA methylation in the pathogenesis of type 2 diabetes in humans

Cajsa Davegårdh, Sonia García-Calzón, Karl Bacos, Charlotte Ling
(2018) Molecular Metabolism, 14 p.12-25
Journal article

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

Elin Hall, Marloes Dekker Nitert, Petr Volkov, Siri Malmgren, Hindrik Mulder, et al.
(2018) Molecular and Cellular Endocrinology, 472 p.57-67
Journal article

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

Marie Balslev Backe, Jan Legaard Andersson, Karl Bacos, Dan Ploug Christensen, Jakob Bondo Hansen, et al.
(2018) Molecular and Cellular Endocrinology, 460 p.47-56
Journal article

Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels

Sonia García-Calzón, Alexander Perfilyev, Vanessa D. de Mello, Jussi Pihlajamäki, Charlotte Ling
(2018) The Journal of clinical endocrinology and metabolism, 103 p.4395-4408
Journal article

DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes

Emma Nilsson, Charlotte Ling
(2017) Clinical Epigenetics, 9
Journal article review

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa de Mello, Emma A Nilsson, et al.
(2017) Clinical Epigenetics, 9 p.1-9
Journal article

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

Line Hjort, Sine W Jørgensen, Linn Gillberg, Elin Hall, Charlotte Brøns, et al.
(2017) Clinical Epigenetics, 9
Journal article

Fetal hyperglycemia changes human preadipocyte function in adult life

Ninna Schiøler Hansen, Klaudia Stanislawa Strasko, Line Hjort, Louise Kelstrup, Azadeh Houshmand-ØRegaard, et al.
(2017) Journal of Clinical Endocrinology and Metabolism, 102 p.1141-1150
Journal article

Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue : A randomized controlled trial

Alexander Perfilyev, Ingrid Dahlman, Linn Gillberg, Fredrik Rosqvist, David Iggman, et al.
(2017) American Journal of Clinical Nutrition, 105 p.991-1000
Journal article

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

Vanessa de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, et al.
(2017) Epigenetics, 12 p.287-295
Journal article

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

Cajsa Davegårdh, Christa Broholm, Alexander Perfilyev, Tora Henriksen, Sonia García-Calzón, et al.
(2017) BMC Medicine, 15 p.1-27
Journal article

Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

Madhusudhan Bysani, Alexander Perfilyev, Vanessa de Mello, Tina Rönn, Emma Nilsson, et al.
(2017) Epigenomics, 9 p.105-122
Journal article

Whole-genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis

Petr Volkov, Karl Bacos, Jones K Ofori, Jonathan Lou S Esguerra, Lena Eliasson, et al.
(2017) Diabetes, 66 p.1074-1085
Journal article

Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

Maria Keller, Lydia Hopp, Xuanshi Liu, Tobias Wohland, Kerstin Rohde, et al.
(2017) Molecular Metabolism, 6 p.86-100
Journal article

Hepatic DPP4 DNA methylation associates with fatty liver

Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, et al.
(2017) Diabetes, 66 p.25-35
Journal article

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

Mahboubeh Daneshpajooh, Karl Bacos, Madhusudhan Bysani, Annika Bagge, Emilia Ottosson Laakso, et al.
(2017) Diabetologia, 60 p.116-125
Journal article

Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes

Christa Broholm, Anders Henrik Olsson, Alexander Perfilyev, Linn Gillberg, Ninna Schiøler Hansen, et al.
(2016) Epigenomics, 8 p.1601-1617
Journal article

Epigenetic programming of adipose-derived stem cells in low birthweight individuals

Christa Broholm, Anders H. Olsson, Alexander Perfilyev, Ninna S. Hansen, Maren Schrölkamp, et al.
(2016) Diabetologia, 59 p.2664-2673
Journal article

Epigenetic markers to further understand insulin resistance

Charlotte Ling, Tina Rönn
(2016) Diabetologia, 59 p.2295-2297
Journal article (comment)

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

Tasnim Dayeh, Tiinamaija Tuomi, Peter Almgren, Alexander Perfilyev, Per Anders Jansson, et al.
(2016) Epigenetics, 11 p.482-488
Journal article

A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits

Petr Volkov, Anders H. Olsson, Linn Gillberg, Sine W. Jørgensen, Charlotte Brøns, et al.
(2016) PLoS ONE, 11
Journal article

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

Heshan Peiris, Michael D. Duffield, Joao Fadista, Claire F. Jessup, Vinder Kashmir, et al.
(2016) PLoS Genetics, 12
Journal article

Developmental programming : State-of-the-science and future directions: Summary from a Pennington Biomedical symposium

Elizabeth F Sutton, L Anne Gilmore, David B Dunger, Bas T Heijmans, Marie-France Hivert, et al.
(2016) Obesity, 24 p.1018-1026
Journal article review

Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.

Linn Gillberg, Alexander Perfilyev, Charlotte Brøns, Martin Thomasen, Louise G Grunnet, et al.
(2016) Diabetologia, 59 p.799-812
Journal article

Epigenetics in type 2 diabetes

Charlotte Ling, Lorenzo Pasquali
(2016) The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation , p.241-258
Book chapter

NIH working group report-using genomic information to guide weight management: From universal to precision treatment.

Molly S Bray, Ruth J F Loos, Jeanne M McCaffery, Charlotte Ling, Paul Franks, et al.
(2016) Obesity, 24 p.14-22
Journal article review

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Karl Bacos, Linn Gillberg, Petr Volkov, Anders H Olsson, Torben Hansen, et al.
(2016) Nature Communications, 7
Journal article

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome

Milana Kokosar, Anna Benrick, Alexander Perfilyev, Romina Fornes, Emma A Nilsson, et al.
(2016) Scientific Reports, 6
Journal article

Risk för typ 2-diabetes kunde förutspås med epigenetik

Karl Bacos, Charlotte Ling
(2016) Läkartidningen, 113
Journal article (comment)

Genome-Wide DNA and Histone Modification Studies in Metabolic Disease

Charlotte Ling, Tina Rönn
(2015) Epigenomics in Health and Disease , p.255-270
Book chapter

The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes.

Linn Gillberg, Charlotte Ling
(2015) Frontiers in Endocrinology, 6
Journal article review

Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?

Tasnim Dayeh, Charlotte Ling
(2015) Biochemistry and Cell Biology, 93 p.511-521
Journal article review

DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes.

Tina Rönn, Charlotte Ling
(2015) Epigenomics, 7 p.451-460
Journal article review

Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.

Emma A Nilsson, Ashok Matte, Alexander Perfilyev, Vanessa D de Mello, Pirjo Käkelä, et al.
(2015) Journal of Clinical Endocrinology and Metabolism, 100 p.1491-1501
Journal article

Helsinki alert of biodiversity and health

Leena von Hertzen, Bruce Beutler, John Bienenstock, Martin Blaser, Patrice D. Cani, et al.
(2015) Annals of Medicine, 47 p.218-225
Journal article review

The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.

I Dahlman, I Sinha, H Gao, D Brodin, A Thorell, et al.
(2015) International Journal of Obesity, 39 p.910-919
Journal article

Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.

Carl Ekman, Targ Elgzyri, Kristoffer Ström, Peter Almgren, Hemang Parikh, et al.
(2015) Journal of Applied Physiology, 119 p.953-960
Journal article

Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.

Tina Rönn, Petr Volkov, Linn Gillberg, Milana Kokosar, Alexander Perfilyev, et al.
(2015) Human Molecular Genetics, 24 p.3792-3813
Journal article

Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Elisabet Agardh, Annika Lundstig, Alexander Perfilyev, Petr Volkov, Tove Freiburghaus, et al.
(2015) BMC Medicine, 13
Journal article

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Elin Hall, Petr Volkov, Tasnim Dayeh, Karl Bacos, Tina Rönn, et al.
(2014) BMC Medicine, 12
Journal article

Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets

Elin Hall, Petr Volkov, Tasnim Dayeh, Jonathan Esguerra, Sofia Salo, et al.
(2014) GenomeBiology, 15
Journal article

Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding

Stine C. Jacobsen, Linn Gillberg, Jette Bork-Jensen, Rasmus Ribel-Madsen, Ester Lara, et al.
(2014) Diabetologia, 57 p.1154-1158
Journal article

A Central Role for GRB10 in Regulation of Islet Function in Man.

Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad, S Albert Salehi, et al.
(2014) PLoS Genetics, 10
Journal article

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.

Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma A Nilsson, et al.
(2014) PLoS Genetics, 10
Journal article

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment.

Philippe A Halban, Kenneth S Polonsky, Donald W Bowden, Meredith A Hawkins, Charlotte Ling, et al.
(2014) Diabetes Care, 37 p.1751-1758
Journal article

Epigenetic adaptation to regular exercise in humans.

Charlotte Ling, Tina Rönn
(2014) Drug Discovery Today, 19 p.1015-1018
Journal article review

Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.

Tina Rönn, Petr Volkov, Åsa Tornberg, Targ Elgzyri, Ola Hansson, et al.
(2014) Acta Physiologica, 211 p.188-200
Journal article

β-cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment.

Philippe A Halban, Kenneth S Polonsky, Donald W Bowden, Meredith A Hawkins, Charlotte Ling, et al.
(2014) Journal of Clinical Endocrinology and Metabolism, 99 p.1983-1992
Journal article

Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes.

Emma A Nilsson, Per Anders Jansson, Alexander Perfilyev, Petr Volkov, Maria Pedersen, et al.
(2014) Diabetes, 63 p.2962-2976
Journal article

Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets.

Anders H Olsson, Petr Volkov, Karl Bacos, Tasnim Dayeh, Elin Hall, et al.
(2014) PLoS Genetics, 10
Journal article

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

Elin Hall, Tasnim Dayeh, Clare L Kirkpatrick, Claes Wollheim, Marloes Dekker Nitert, et al.
(2013) BMC Medical Genetics, 14
Journal article

Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?

Linn Gillberg, Stine Jacobsen, Rasmus Ribel-Madsen, Anette Prior Gjesing, Trine W. Boesgaard, et al.
(2013) PLoS ONE, 8
Journal article

A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.

Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, et al.
(2013) PLoS Genetics, 9
Journal article

Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.

Siri Malmgren, Peter Spégel, Anders Danielsson, Cecilia Nagorny, Lotta Andersson, et al.
(2013) Journal of Biological Chemistry, 288 p.11973-11987
Journal article

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.

Tasnim Dayeh, Anders H Olsson, Petr Volkov, Peter Almgren, Tina Rönn, et al.
(2013) Diabetologia, 56 p.1036-1046
Journal article

Effect of exercise on DNA methylation and metabolism in human adipose tissue and skeletal muscle.

Tina Rönn, Charlotte Ling
(2013) Epigenomics, 5 p.603-605
Journal article (comment)

Osteocalcin, glucose metabolism, lipid profile and chronic low-grade inflammation in middle-aged and elderly Chinese.

Chen Ling, Qi Li, Z Yang, Z Ye, Yuan Huang, et al.
(2013) Diabetic Medicine, 30 p.309-317
Journal article

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.

Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, et al.
(2012) Diabetes
Journal article

A Single Nucleotide Polymorphism Associates With the Response of Muscle ATP Synthesis to Long-Term Exercise Training in Relatives of Type 2 Diabetic Humans

Gertrud Kacerovsky-Bielesz, Michaela Kacerovsky, Marek Chmelik, Michaela Farukuoye, Charlotte Ling, et al.
(2012) Diabetes Care, 35 p.350-357
Journal article

Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes.

Beatrice Yang, Tasnim Dayeh, Petr Volkov, Clare L Kirkpatrick, Siri Malmgren, et al.
(2012) Molecular Endocrinology, 26 p.1203-1212
Journal article

First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.

Targ Elgzyri, Hemang Parikh, Yuedan Zhou, Marloes Dekker Nitert, Tina Rönn, et al.
(2012) Journal of Clinical Endocrinology and Metabolism, 97 p.1332-1337
Journal article

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

S. C. Jacobsen, C. Brons, J. Bork-Jensen, R. Ribel-Madsen, Beatrice Yang, et al.
(2012) Diabetologia, 55 p.3341-3349
Journal article

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.

Sofia A Andersson, Anders H Olsson, Jonathan L S Esguerra, Emilia Heimann, Claes Ladenvall, et al.
(2012) Molecular and Cellular Endocrinology, 364 p.36-45
Journal article

PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population

Zhen Yang, Jie Wen, Qin Li, Xiaoming Tao, Zi Ye, et al.
(2012) Molecular and Cellular Endocrinology, 348 p.255-259
Journal article

Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.

Shafqat Ahmad, A Heraclides, Q Sun, Targ Elgzyri, Tina Rönn, et al.
(2012) Diabetic Medicine: A journal of the British Diabetic Association, 29 p.377-381
Journal article

Regulation of core clock genes in human islets.

Jelena Stamenkovic, Anders H Olsson, Cecilia Nagorny, Siri Malmgren, Marloes Dekker Nitert, et al.
(2012) Metabolism, Clinical and Experimental, 61 p.978-985
Journal article

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.

Beatrice Yang, Tasnim Dayeh, C L Kirkpatrick, Jalal Taneera, Rajesh Kumar, et al.
(2011) Diabetologia, Dec p.360-367
Journal article

Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects.

Matteo Riva, Marloes Dekker Nitert, Ulrikke Voss, Ramasri Sathanoori, Andreas Lindqvist, et al.
(2011) Cell and Tissue Research, 346 p.393-405
Journal article

Two common genetic variants near nuclear encoded OXPHOS genes are associated with insulin secretion in vivo.

Anders H Olsson, Tina Rönn, Claes Ladenvall, Hemang Parikh, Bo Isomaa, et al.
(2011) European Journal of Endocrinology, 164 p.765-771
Journal article

A common variant near the PRL gene is associated with increased adiposity in males

Louise Nilsson, Anders H Olsson, Bo Isomaa, Leif Groop, Hakan Billig, et al.
(2011) Molecular Genetics and Metabolism, 102 p.78-81
Journal article

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

Ionel Sandovici, Noel H. Smith, Marloes Dekker Nitert, Matthew Ackers-Johnson, Santiago Uribe-Lewis, et al.
(2011) Proceedings of the National Academy of Sciences, 108 p.5449-5454
Journal article

Prevalence of non-alcoholic fatty liver disease and its relation to hypoadiponectinaemia in the middle-aged and elderly Chinese population

Zhen Yang, Xuanchun Wang, Jie Wen, Zi Ye, Qin Li, et al.
(2011) Archives of Medical Science, 7 p.665-672
Journal article

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.

Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
(2011) Cell Metabolism, 13 p.80-91
Journal article

Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes.

Anders H Olsson, Beatrice Yang, Elin Hall, Jalal Taneera, S Albert Salehi, et al.
(2011) European Journal of Endocrinology, 165 p.589-595
Journal article

The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.

Anders H Olsson, Tina Rönn, Tarq Elgzyri, Ola Hansson, Karl-Fredrik Eriksson, et al.
(2011) Molecular Genetics and Metabolism, 103 p.275-281
Journal article

Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

Zhen Yang, Jie Wen, Xiaoming Tao, Bin Lu, Yanping Du, et al.
(2011) Molecular Biology Reports, 38 p.1145-1150
Journal article

THE ROLE OF SNARE PROTEINS IN HUMAN INSULIN RESISTANCE

P. Bostrom, L. Andersson, B. Vind, L. Haversen, Y. Wickstrom, et al.
(2010) Atherosclerosis Supplements, 11 p.283-283
Conference paper: abstract

Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort

Jie Wen, Tina Rönn, Anders H Olsson, Zhen Yang, Bin Lu, et al.
(2010) PLoS ONE, 5
Journal article

Epigenetics and obesity: the devil is in the details

Paul Franks, Charlotte Ling
(2010) BMC Medicine, 8
Journal article (comment)

The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes

Pontus Bostrom, Linda Andersson, Birgitte Vind, Liliana Haversen, Mikael Rutberg, et al.
(2010) Diabetes, 59 p.1870-1878
Journal article

A lipotoxicity model in the INS-1 832/13 beta cell line and the epigenetic alterations induced by it

Siri Malmgren, Vladimir Sharoyko, David Nicholls, Cecilia Nagorny, Peter Spégel, et al.
(2010) Diabetologia, 53 p.348-348
Conference paper: abstract

Melatonin effects on insulin secretion and clock genes expression

Jelena Stamenkovic, Cecilia Nagorny, Charlotte Ling, S Albert Salehi, Vladimir Sharoyko, et al.
(2010) Diabetologia, 53 p.93-93
Conference paper: abstract

A mRNA marker for glycolytic muscle fibres may be used to determine fibre type composition in human skeletal muscle

Anders H Olsson, Targ Elgzyri, Esa Laurila, Leif Groop, Ola Hansson, et al.
(2010) Diabetologia, 53 p.705-705
Conference paper: abstract

Resistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes

Marloes Dekker Nitert, Tasnim Dayeh, Stefan Lang, Targ Elgzyri, Yang De Marinis, et al.
(2010) Diabetologia, 53 p.312-312
Conference paper: abstract

Nesfatin-1 stimulates insulin secretion, inhibits glucagon secretion and is expressed in human and rodent beta cells

Ulrikke Voss, Matteo Riva, Marloes Dekker Nitert, Charlotte Ling, Anders Lindqvist, et al.
(2010) Diabetologia, 53 p.548-548
Conference paper: abstract

Oxidative phosphorylation-dependent insulin secretion in pancreatic beta cells: new insights by disrupting TFB1M

Thomas Köck, Peter Spégel, Vladimir Sharoyko, Charlotte Ling, Hindrik Mulder
(2010) Diabetologia, 53 p.491-491
Conference paper: abstract

The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes.

Erwin Reiling, Charlotte Ling, André G Uitterlinden, Esther Van't Riet, Laura M C Welschen, et al.
(2010) The Journal of clinical endocrinology and metabolism, 95 p.1909-1915
Journal article

Elevated Serum Chemokine CXC Ligand 5 Levels Are Associated with Hypercholesterolemia But Not a Worsening of Insulin Resistance in Chinese People.

Zhen Yang, Zhaoyun Zhang, Jie Wen, Xuanchun Wang, Bin Lu, et al.
(2010) The Journal of clinical endocrinology and metabolism, 95 p.3926-3932
Journal article

Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner.

Charlotte Brøns, Stine Jacobsen, Emma E Nilsson, Tina Rönn, Christine B Jensen, et al.
(2010) The Journal of clinical endocrinology and metabolism, 95 p.3048-3056
Journal article

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

Charlotte Ling, Leif Groop
(2009) Diabetes, 58 p.2718-2725
Journal article review

Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue

Louise G. Grunnet, Emma Nilsson, Charlotte Ling, Torben Hansen, Oluf Pedersen, et al.
(2009) Diabetes, 58 p.2402-2408
Journal article

Prolactin Suppresses Malonyl-CoA Concentration in Human Adipose Tissue

L. A. Nilsson, C. Roepstorff, B. Kiens, H. Billig, Charlotte Ling
(2009) Hormone and Metabolic Research, 41 p.747-751
Journal article

Effects of six months of moderate resistance-versus endurance-training on muscle ATP synthesis in first-degree relatives of patients with type 2 diabetes

G. Kacerovsky-Bielesz, M. Chmelik, Charlotte Ling, R. Pokan, J. Szendroedi, et al.
(2009) Diabetologia, 52 p.687-687
Conference paper: abstract

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 Diabetes.

Hindrik Mulder, Charlotte Ling
(2009) Molecular and Cellular Endocrinology, 297 p.34-40
Journal article

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.

Tina Rönn, J Wen, Z Yang, B Lu, Y Du, et al.
(2009) Diabetologia, Feb 25 p.830-833
Journal article

Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.

Tina Rönn, Pernille Poulsen, Tiinamaija Tuomi, Bo Isomaa, Leif Groop, et al.
(2009) PLoS ONE, 4
Journal article

Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.

Charlotte Ling, Leif Groop, Silvia Del Guerra, Roberto Lupi
(2009) PLoS ONE, 4
Journal article

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.

Siri Malmgren, David Nicholls, Jalal Taneera, Karl Bacos, Thomas Koeck, et al.
(2009) Journal of Biological Chemistry, 284 p.32395-32404
Journal article

Disruption of TFB1M impairs insulin secretion in beta cells

Thomas Köck, Marloes Dekker Nitert, A Olsson, Olga Kotova, Jelena Stamenkovic, et al.
(2009) Diabetologia, 52 p.116-116
Conference paper: abstract

Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes

Gertrud Kacerovsky-Bielesz, Marek Chmelik, Charlotte Ling, Rochus Pokan, Julia Szendroedi, et al.
(2009) Diabetes, 58 p.1333-1341
Journal article

Genetic variation in ATP5O is associated with mRNA expression in human skeletal muscle and in vivo glucose uptake

Tina Rönn, P. Poulsen, Leif Groop, A. Vaag, Charlotte Ling
(2008) Diabetologia, 51 p.132-132
Conference paper: abstract

PGC-1 alpha and PGC-1 beta are related to markers for fibre type composition in human skeletal muscle

Anders H Olsson, Tina Rönn, A. Vaag, Leif Groop, P. Poulsen, et al.
(2008) Diabetologia, 51 p.130-130
Conference paper: abstract

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

Tina Rönn, P Poulsen, Ola Hansson, Johan Holmkvist, Peter Almgren, et al.
(2008) Diabetologia, 51 p.1159-1168
Journal article

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.

Charlotte Ling, S Del Guerra, R Lupi, Tina Rönn, Charlotte Granhall, et al.
(2008) Diabetologia, 51 p.615-622
Journal article

Molecular correlates for maximal oxygen uptake (VO2max) and type 1 fibers.

Hemang Parikh, Emma Nilsson, Charlotte Ling, Pernille Poulsen, Peter Almgren, et al.
(2008) American Journal of Physiology: Endocrinology and Metabolism, Apr 29 p.1152-1159
Journal article

Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: Evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice

Ruijin Shao, Magdalena Nutu, Birgitta Weijdegard, Emil Egecioglu, Julia Fernandez-Rodriguez, et al.
(2008) Biology of Reproduction, 79 p.748-757
Journal article

Impact of the peroxisome proliferator activated receptor-gamma coactivator-1 beta (PGC-1 beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1 beta expression and fibre type composition in human skeletal muscle

Charlotte Ling, L. Wegner, G. Andersen, Peter Almgren, T. Hansen, et al.
(2007) Diabetologia, 50 p.1615-1620
Journal article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Valeriya Lyssenko, Roberto Lupi, Piero Marchetti, Silvia Del Guerra, Marju Orho-Melander, et al.
(2007) Journal of Clinical Investigation, 117 p.2155-2163
Journal article

Regulation of skeletal muscle PPAR delta mRNA expression in twins

Emma Nilsson, Pernille Poulsen, Marketa Sjögren, Charlotte Ling, Martin Ridderstråle, et al.
(2007) Journal of Physiology, 584 p.1011-1017
Journal article

Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins.

Heidi Storgaard, Pernille Poulsen, Charlotte Ling, Leif Groop, Allan A Vaag
(2007) Journal of Clinical Endocrinology and Metabolism, 92 p.2835-2839
Journal article

Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

Charlotte Ling, Pernille Poulsen, Stina Simonsson, Tina Rönn, Johan Holmkvist, et al.
(2007) Journal of Clinical Investigation, 117 p.3427-3435
Journal article

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Malin Fex, Marloes Dekker Nitert, Nils Wierup, Frank Sundler, Charlotte Ling, et al.
(2007) Diabetologia, 50 p.74-83
Journal article

Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors

Ruijin Shao, Emil Egecioglu, Birgitta Weijdegard, Karin Ljungstrom, Charlotte Ling, et al.
(2006) Journal of Endocrinology, 190 p.857-870
Journal article

Genetic and nongenetic determinants of skeletal muscle glucose transporter 4 messenger ribonucleic acid levels and insulin action in twins

H Storgaard, P Poulsen, Charlotte Ling, Leif Groop, A A Vaag
(2006) Journal of Clinical Endocrinology and Metabolism, 91 p.702-708
Journal article

Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue

Charlotte Ling, Louise Svensson, Birgitta Oden, Birgitta Weijdegard, Barbro Eden, et al.
(2003) Journal of Clinical Endocrinology and Metabolism, 88 p.1804-1808
Journal article

Charlotte Ling

Publications