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Cecilia Holm

Professor

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Particle separation using ultrasound can radically reduce embolic load to brain after cardiac surgery.

Author

  • Henrik Bjursten
  • Cecilia Holm
  • Andreas Lenshof
  • Filip Pettersson
  • Per Johansson
  • Thomas Laurell

Summary, in English

Background. Microembolism during cardiopulmonary bypass has been suggested as being the predominant cause of neurocognitive disorders after cardiac surgery. Shed blood, normally retransfused into the patient during cardiopulmonary bypass, is a major source of lipid microemboli in the brain capillaries. A newly developed technique based on acoustic standing-wave separation of particles in fluid in microchannels, with the capacity to remove lipid particles in blood, is presented. Methods. A separator consisting of eight parallel, high-fidelity microfabricated channels was actuated with an ultrasound field to create a standing wave. Three different concentrations of lipid particles (diameter, 0.3 mum) were added to blood samples with increasing hematocrits and introduced into the separator channels to separate lipid particles and erythrocytes. Results. The mean separation rates for lipid particles were 81.9% +/- 7.6% and for erythrocytes 79.8% +/- 9.9%, and both were related to the hematocrit level of the incoming blood sample. The procedure was atraumatic and did not cause hemolysis. Conclusions. Particle separation by means of an acoustic standing-wave technique can be used for atraumatic and effective removal of lipid particles from blood, with the possible clinical implication of reducing neurocognitive complications after cardiopulmonary bypass. (C) 2004 by The Society of Thoracic Surgeons.

Department/s

  • Thoracic Surgery
  • Molecular Endocrinology
  • Department of Biomedical Engineering

Publishing year

2004

Language

English

Pages

1572-1578

Publication/Series

Annals of Thoracic Surgery

Volume

78

Issue

5

Document type

Journal article

Publisher

Elsevier

Topic

  • Surgery
  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Molecular Endocrinology

ISBN/ISSN/Other

  • ISSN: 1552-6259