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Cecilia Holm

Professor

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Cereal Byproducts Have Prebiotic Potential in Mice Fed a High-Fat Diet

Author

  • Karin Berger
  • Peter Falck
  • Caroline Linninge
  • Ulf Nilsson
  • Ulrika Axling
  • Carl Grey
  • Henrik Stålbrand
  • Eva Nordberg Karlsson
  • Margareta Nyman
  • Cecilia Holm
  • Patrick Adlercreutz

Summary, in English

Barley husks, rye bran, and a fiber residue from oat milk production were processed by heat pretreatment, various
separation steps, and treatment with an endoxylanase in order to improve the prebiotic potential of these cereal byproducts.
Metabolic functions were intended to improve along with improved microbial activity. The products obtained were included in a
high-fat mouse diet so that all diets contained 5% dietary fiber. In addition, high-fat and low-fat controls as well as partially
hydrolyzed guar gum were included in the study. The soluble fiber product obtained from rye bran caused a significant increase
in the bifidobacteria (log copies of 16S rRNA genes; median (25−75 percentile): 6.38 (6.04−6.66) and 7.47 (7.30−7.74),
respectively; p < 0.001) in parallel with a tendency of increased production of propionic acid and indications of improved
metabolic function compared with high-fat fed control mice. The oat-derived product caused an increase in the pool of cecal
propionic (from 0.62 ± 0.12 to 0.94 ± 0.08) and butyric acid (from 0.38 ± 0.04 to 0.60 ± 0.04) compared with the high-fat
control, and it caused a significant increase in lactobacilli (log copies of 16S rRNA genes; median (25−75 percentile): 6.83
(6.65−7.53) and 8.04 (7.86−8.33), respectively; p < 0.01) in the cecal mucosa. However, no changes in measured metabolic
parameters were observed by either oat or barley products.

Department/s

  • Molecular Nutrition
  • Biotechnology
  • Department of Food Technology, Engineering and Nutrition
  • Molecular Endocrinology
  • Biochemistry and Structural Biology
  • Food for Health Science Centre, Kemicentrum
  • Food for Health Science Centre
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2014-08

Language

English

Pages

8169-8178

Publication/Series

Journal of Agricultural and Food Chemistry

Volume

62

Issue

32

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Agricultural Science, Forestry and Fisheries

Keywords

  • dietary fiber
  • C57BL/6 mice
  • gut microbiota
  • short-chain fatty acids (SCFAs)
  • xylanase

Status

Published

Project

  • ANTIDIABETIC FOOD CENTRE

Research group

  • Molecular Nutrition
  • Molecular Endocrinology

ISBN/ISSN/Other

  • ISSN: 0021-8561