
Cecilia Holm
Professor

Cereal Byproducts Have Prebiotic Potential in Mice Fed a High-Fat Diet
Author
Summary, in English
separation steps, and treatment with an endoxylanase in order to improve the prebiotic potential of these cereal byproducts.
Metabolic functions were intended to improve along with improved microbial activity. The products obtained were included in a
high-fat mouse diet so that all diets contained 5% dietary fiber. In addition, high-fat and low-fat controls as well as partially
hydrolyzed guar gum were included in the study. The soluble fiber product obtained from rye bran caused a significant increase
in the bifidobacteria (log copies of 16S rRNA genes; median (25−75 percentile): 6.38 (6.04−6.66) and 7.47 (7.30−7.74),
respectively; p < 0.001) in parallel with a tendency of increased production of propionic acid and indications of improved
metabolic function compared with high-fat fed control mice. The oat-derived product caused an increase in the pool of cecal
propionic (from 0.62 ± 0.12 to 0.94 ± 0.08) and butyric acid (from 0.38 ± 0.04 to 0.60 ± 0.04) compared with the high-fat
control, and it caused a significant increase in lactobacilli (log copies of 16S rRNA genes; median (25−75 percentile): 6.83
(6.65−7.53) and 8.04 (7.86−8.33), respectively; p < 0.01) in the cecal mucosa. However, no changes in measured metabolic
parameters were observed by either oat or barley products.
Department/s
- Molecular Nutrition
- Biotechnology
- Department of Food Technology, Engineering and Nutrition
- Molecular Endocrinology
- Biochemistry and Structural Biology
- Food for Health Science Centre, Kemicentrum
- Food for Health Science Centre
- EXODIAB: Excellence of Diabetes Research in Sweden
Publishing year
2014-08
Language
English
Pages
8169-8178
Publication/Series
Journal of Agricultural and Food Chemistry
Volume
62
Issue
32
Links
Document type
Journal article
Publisher
The American Chemical Society (ACS)
Topic
- Agricultural Science, Forestry and Fisheries
Keywords
- dietary fiber
- C57BL/6 mice
- gut microbiota
- short-chain fatty acids (SCFAs)
- xylanase
Status
Published
Project
- ANTIDIABETIC FOOD CENTRE
Research group
- Molecular Nutrition
- Molecular Endocrinology
ISBN/ISSN/Other
- ISSN: 0021-8561