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Cecilia Holm

Professor

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Adiponutrin: A multimeric plasma protein.

Author

  • Martin Tinnerfelt Winberg
  • Mahshid Khalaj Motlagh
  • Karin Stenkula
  • Cecilia Holm
  • Helena Jones

Summary, in English

The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma makes it accessible for clinical investigations and use as a potential biomarker for metabolic disease.

Department/s

  • Molecular Endocrinology
  • Department of Experimental Medical Science
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2014

Language

English

Pages

1114-1119

Publication/Series

Biochemical and Biophysical Research Communications

Volume

446

Issue

4

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Status

Published

Research group

  • Molecular Endocrinology

ISBN/ISSN/Other

  • ISSN: 1090-2104