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Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms.

Author:
  • Carl Ekman
  • Despina Flondell-Sité
  • Anders Gottsäter
  • Bengt Lindblad
  • Björn Dahlbäck
Publishing year: 2010
Language: English
Pages: 110-114
Publication/Series: Clinical Biochemistry
Volume: 43
Document type: Journal article
Publisher: Elsevier

Abstract english

OBJECTIVE: The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. DESIGN AND METHODS: Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141). RESULTS: Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients with a large AAA had higher Gas6/sAxl ratio than any in the control group. DISCUSSION: The Gas6/Axl system might be involved in AAA pathogenesis, and the Gas6/sAxl ratio may be useful as a biomarker.

Keywords

  • Biochemistry and Molecular Biology

Other

Published
  • Clinical Chemistry, Malmö
  • Vascular Diseases - Clinical Research
  • ISSN: 1873-2933
E-mail: carl [dot] ekman [at] med [dot] lu [dot] se

Postdoctoral fellow

Genomics, Diabetes and Endocrinology

33

Research project participant

Genomics, Diabetes and Endocrinology

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00