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Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.

  • Carl Ekman
  • Targ Elgzyri
  • Kristoffer Ström
  • Peter Almgren
  • Hemang Parikh
  • Marloes Dekker Nitert
  • Tina Rönn
  • Fiona Koivula
  • Charlotte Ling
  • Åsa Tornberg
  • Per Wollmer
  • Karl-Fredrik Eriksson
  • Leif Groop
  • Ola Hansson
Publishing year: 2015
Language: English
Pages: 953-960
Publication/Series: Journal of Applied Physiology
Volume: 119
Issue: 9
Document type: Journal article
Publisher: American Physiological Society
Additional info: The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Epigenetics and Diabetes (013241505), Physiotherapy (013220009), Faculty of Medicine (000022000), Molecular Metabolism (013212001), Diabetes and Endocrinology (013241530), Clinical Physiology and Nuclear Medicine Unit (013242320), Unit for Clinical Vascular Disease Research (013242410)

Abstract english

Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility when compared to subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared to FH-. 16 FH+ and 19 FH- insulin sensitive men similar in age, VO2peak and BMI completed an exercise intervention with heart rate monitoration during exercise for 7 months. Before and after the exercise intervention, the participants underwent a physical examination, tests for glucose tolerance and exercise capacity and muscle biopsies were taken for expression analysis. The participants attended on average 39 training sessions during the intervention and spent 18.8 MJ on exercise. VO2peak/kg increased by 14% and the participants lost 1.2 kg of weight and 3 cm waist circumference. Given that the FH+ group expended 61% more energy during the intervention, we used regression analysis to analyze the response in the FH+ and FH- groups separately. Exercise volume had a significant effect on VO2peak, weight and waist circumference in the FH- group, but not in the FH+ group. After exercise, expression of genes involved in metabolism, oxidative phosphorylation and cellular respiration increased more in the FH-, compared to the FH+ group. This suggests that healthy, insulin sensitive FH+ and FH- participants with similar age, VO2peak and BMI may respond differently to an exercise intervention. The FH+ background might limit muscle adaptation to exercise, which may contribute to the increased susceptibility to type 2 diabetes in FH+ individuals.


  • Endocrinology and Diabetes


  • Genomics, Diabetes and Endocrinology
  • Diabetes - Epigenetics
  • Physiotherapy
  • Clinical Physiology, Malmö
  • Vascular Diseases - Clinical Research
  • ISSN: 1522-1601

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