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Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus.

Author:
  • Carl Ekman
  • Andreas Jönsen
  • Gunnar Sturfelt
  • Anders Bengtsson
  • Björn Dahlbäck
Publishing year: 2011
Language: English
Pages: 1064-1069
Publication/Series: Rheumatology (Oxford, England)
Volume: 50
Document type: Journal article
Publisher: Oxford University Press

Abstract english

Objectives. SLE is a systemic autoimmune disease with an annual incidence of 3.8 per 100 000. Several pathogenic mechanisms are believed to be operating in SLE, including an impaired clearance of apoptotic cells, activation of the type I IFN pathway and generation of autoimmune leucocytes. Growth arrest-specific protein 6 (Gas6) and its receptor Axl are known to regulate inflammation and may be implicated in lupus pathogenesis. We have recently developed immunological methods to quantify the vitamin-K-dependent protein Gas6 and its soluble receptor sAxl in human plasma, which we have used to investigate the role of Gas6 and soluble Axl in SLE. Methods. We have investigated the relation between the plasma concentrations of Gas6 and sAxl and disease activity and specific symptoms in 96 SLE patients. Results. Gas6 and sAxl concentrations correlated with SLEDAI (r = 0.48, P < 0.001 and r = 0.39, P < 0.001, respectively). Furthermore, concentrations of Gas6 and sAxl correlated with ESR and CRP and inversely with haemoglobin levels. Gas6 and sAxl concentrations were significantly higher in patients with anti-DNA antibodies, leucopenia and GN. Conclusion. The plasma concentrations of Gas6 and sAxl vary with disease activity in SLE, in particular GN, and may have a role in lupus pathogenesis. Furthermore, Gas6 and sAxl may be of use as biomarkers of disease activity.

Keywords

  • Rheumatology and Autoimmunity

Other

Published
  • Clinical Chemistry, Malmö
  • ISSN: 1462-0332
E-mail: carl [dot] ekman [at] med [dot] lu [dot] se

Postdoctoral fellow

Genomics, Diabetes and Endocrinology

33

Research project participant

Genomics, Diabetes and Endocrinology

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00